23 Drug Discovery, Pharmaceuticals & Cannabis Testing
Ion chromatography for the pharmaceutical industry
Ion chromatography (IC) is an analytical technique used to separate and quantify ionic and polar analytes. It’s now widely accepted by the pharmaceutical industry and regulatory bodies for an expanded range of applications like water quality and chemical analysis.
During their modernisation initiative, the US Pharmacopeia-National Formulary (USP), the driving standardisation body for pharmaceutical products, recognised IC’s potential, establishing it as an appropriate and valid technique. The reasoning behind this was to ensure the pharmaceutical industry was integrating well with modern analytical technologies by replacing non-specific tests.
Even though a high-performance liquid chromatography approach is a dominant method in the pharmaceutical industry, IC is growing increasingly popular. This is due to advantages that IC has over other liquid chromatographic or traditional methods.
The ability to separate ions, metals, polar molecules, and even non-ionic polar compounds offers IC users unique advantages. With IC, there is no need for special waste handling, plus the access to multiple detection options significantly widens the field of suitable applications.
IC is a powerful, versatile analytical tool for pharmaceutical applications. It’s capable of handling a wide variety of sample types and provides high sensitivity when detecting ionic and ionisable substances. IC’s ability to couple different detection strategies makes it invaluable in pharmaceutical manufacturing and for quality control.
More information online:
ilmt.co/PL/Lx9y 63954pr@reply-direct.com
Ready-to-use hiPSC-derived cells streamline lab workfl ows
AMSBIO has introduced a new range of fully differentiated human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, hepatocytes, and neurons, designed to streamline laboratory workflows. These ready-to-use cells eliminate the need for in-house differentiation, significantly reducing preparation time and enhancing research efficiency.
With functional validation performed prior to delivery, researchers can confidently incorporate these cells into their assays without additional optimisation. This is particularly beneficial for Contract Research Organizations (CROs) and life science laboratories, enabling them to save both time and costs associated with validation processes.
AMSBIO’s hiPSC-derived cells offer exceptional batch-to-batch consistency, ensuring reliable experimental outcomes. By providing a physiologically relevant alternative to primary cells and animal models, these cells support a wide range of applications, including drug discovery, disease modelling, and toxicity screening. More information online:
ilmt.co/PL/Ql1x
64069pr@reply-direct.com ADVERTORIAL Xylem’s specialist analytical products for the cannabis industry
The determination of the water content in cannabis is of great importance for the qualitative assessment of the active components (THC, CBD) as well as its storage stability. Karl Fischer titration offers a selective and reliable alternative to the drying method.
Compared to the reference method of national and international pharmacopoeias, which require a determination via the loss on drying over 24 hours, the Karl Fischer method provides a selective and reproducible result in less than 30 minutes with a signifi cantly smaller sample quantity. The results presented in Xylem’s white paper were obtained using SI Analytics® KF Titrators and KF Headspace Oven from Xylem using industrial hemp containing CBD.
Promoting healthy plant-life and maximising yield Xylem offers several other analytical solutions to the cannabis industry, whether they be for licensed growers, or processors of substances containing cannabidiol (commonly known as CBD).
Cannabis growers should be mindful of temperature and humidity within the growing and storage areas as these parameters are also key for optimal growth, and both can be continually monitored using EBI 25 data loggers with remote alarm features.
In addition, growers can measure how well their plants are developing by using an Eclipse Brix refractometer to measure the sugar content of its sap, which is representative of a plant’s strength.
Processing cannabis forms part of the pharmaceutical, cosmetic, and more recently the food & beverage industry and requires stringent quality control. Amongst other tests, the measurement of optical rotation of cannabidiol by a polarimeter is simple and may be used to determine the purity or blend ratio of CBD type ((-)- or (+)- CBD) as well as used to ensure fi nished product is consistent between batches.
Request Xylem’s Cannabis Whitepaper today. More information online:
ilmt.co/PL/Q6Xz and
ilmt.co/PL/65dY 63109pr@reply-direct.com
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Measurement solutions for reliable, repeatable results to enhance your laboratory
Xylem is a leading provider of premium field, portable, process and laboratory analytical instrumentation for environmental, food, beverage, chemical and pharmaceutical applications.
Our commitment is to provide you with the best products and services so you can solve your measurement challenges.
www.xylemanalytics.com
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