21 Drug Discovery, Pharmaceuticals & Cannabis Testing
Automated sample prep enhances LC/GC cannabis analysis
Tecan introduces the Resolvex Prep, an ideal solution for automating cannabis analysis workflows while using the same labware as manual processes. This platform offers automated syringe change, a wash station, and the ability to pipette into/out of septa-sealed vials, all while precisely handling solvents used in LC/LCMS and GC/GCMS analysis.
Starting with weighed cannabis flowers, the Resolvex Prep automates the entire sample preparation process of extraction, filtration, and final solution preparation, directly into 2 mL autosampler vials, for subsequent chromatographic analysis.
Recent demonstrations have shown excellent performance compared to the previous GMP-validated manual protocol, achieving THCA concentrations of approximately 25.4% and a recovery rate of 99.1% along with a 97.5% recovery rate for terpenoids, confirming the method’s reliability and efficiency.
The Resolvex Prep is capable of handling a wide range of sample matrices including plants, water and soil. It supports various extraction methods, such as SPE and LLE, enhancing its adaptability for diverse applications.
More information online:
ilmt.co/PL/Z6x3 64070pr@reply-direct.com
Simple extraction of THC metabolites from urine with a single plate
Tecan has developed an innovative sample preparation method using its AC Extraction Plate, featuring Tecan Immobilized Coating Extraction (TICE™) technology. This design simplifies the workflow and is ideally suited for automation. The AC Extraction Plate is a 96-well deep well plate that selectively absorbs non-polar small molecules like THC metabolites. This method exhibits excellent linearity for THC- COOH concentrations between 2.5 and 100 ng/ml, with a lower limit of quantitation at 2.5 ng/ml.
The process comprises three rounds of solvent addition, shaking, and solvent removal to:
• add samples and standards • wash off proteins and salts, and
• elute the desired analytes, which can then be directly injected into an LC-MSMS system
This approach eliminates the need for labor- intensive steps like protein precipitation and centrifugation, making it a cost-effective and time-efficient solution for forensic and clinical research applications.
More information online:
ilmt.co/PL/Vbky
64071pr@reply-direct.com
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