17 Mass Spectrometry New Mass Spec Solution Simplifi es Analysis of Macromolecular Complexes
An innovative mass spectrometry solution from Thermo Fisher Scientific Inc provides proteomics and biopharmaceutical laboratories, working in drug discovery and R&D applications, the ability to clearly decipher complex mixtures of large macromolecules.
The Thermo Scientific Direct Mass Technology mode augments Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometers with charge detection capabilities, allowing direct mass determination of hundreds to thousands of individual ions in a single spectrum. As a result, laboratories can measure mass for complex heterogeneous mixtures of multiple charged components, unlocking new and rich insights into proteoforms, biotherapeutics and next-generation drug modalities.
“Direct Mass Technology mode combines charge detection with our trusted high-resolution accurate mass Orbitrap measurements to achieve results unattainable by current ensemble measurement techniques,” said Iain Mylchreest, Vice President, Research and Development, Analytical Instruments, Thermo Fisher Scientific. “By dissolving the complexity barriers inherent to other approaches, we’re enabling a wealth of investigations that were once firmly out of reach - from resolving heavily modified proteoforms to revealing small changes in large antibody-drug conjugate complexes, to name but a few.”
Neil Kelleher, Director, Northwestern Proteomics & the Chemistry of Life Processes Institute, Northwestern University, said: “The differences seen when moving from traditional mass spectrometry to this game-changing direct mass technology are profound. We’ve gone from having no data or uninterpretable data to having rich spectra laying bare proteoform complexity. With such solutions, we no longer need to be overwhelmed by the complexity of the human proteome. This technology makes clear that, ultimately, we can build tools that match the complexity and scale of our biology.”
More information online:
ilmt.co/PL/x9K1 and
ilmt.co/PL/Lyve 58057pr@reply-direct.com
Effective MS Detection for Pure Compound Isolation
Gilson’s single quad VERITY® 1920 Mass Spectrometer is ideal for laboratories seeking effective MS detection when isolating pure compounds. The versatile VERITY 1920 MS can utilise electrospray ionisation (ESI) or atmospheric pressure chemical ionisation (APCI) ion sources, providing application flexibility. The detector can be combined with various Gilson Purification systems to selectively purify active ingredients from small to large molecules and natural products from lab-to pilot-scale.
With the VERITY 1920, you’ll save valuable time and maximise productivity as targeted fraction collection reduces post purification work and purity analysis. Mass directed purification improves collection selectivity, which is especially useful when working with complex samples.
With a mass range of 10–2000 m/z, the VERITY 1920 MS helps you even detect large molecules such as peptides and small proteins. Many biomolecules carry multiple charges with electrospray ionisation so that even proteins of several tens of kDa can be measured within the 2,000 m/z range.
The Verity 1920 MS can add new dimensions to Gilson’s uniquely versatile and powerful PLC Purification and VERITY® CPC systems, bringing greater selectivity from lab to pilot scale purification while making mass detection affordable and straightforward for any preparative purification system.
Contact Gilson for more information on the VERITY 1920 Mass Spectrometer or their range of purification systems. More information online:
ilmt.co/PL/x9JA 57598pr@reply-direct.com ADVERTORIAL Portable Quadrupole Analyser for Environmental Field Studies
The Hiden pQA portable gas analyser is a versatile mass spectrometer and offered with a range of interchangeable sampling inlets to suit a broad application range. MIMS inlets are offered for analysis of dissolved species in ground water, fermentation cultures, soil samples, and general applications where analysis of dissolved species in liquid sample is required.
The system is suited to gas analysis applications, where sample volume is small, and for environmental applications where detection of low concentration levels is required. The pQA system has a mass range of 200 amu and sub ppb detection levels. Extended mass range to 300amu is optional.
The system is supplied in a Pelican® case and can be powered by a 12 V supply for fi eld use, battery and/or solar powered, or a 220 V supply for laboratory use.
Sampling inlet systems are offered for a broad application range including: Direct membrane inlet probe for immersion and/or insertion in liquid or sludge sample, soil core sampling for example; Recirculating probe for analysis of sample with continuous fl ow, extracted sea or estuary water for example; Flow through probe, low fl ow design for denitrifi cation studies.
The system includes: Quadrupole mass spectrometer system from the RGA series with mass range options 200 amu; Mass spectrometer analyser manifold and UHV pump set with a manually valved dissolved species probe with silicone rubber membrane; Ion Gauge and interlocks to provide protection for the mass spectrometer in case of over pressure; fast acting shut off valve between the dissolved species probe and mass spectrometer manifold to protect the mass spectrometer in case of membrane failure - the valve is interlocked with the integral UHV pressure gauge; supplied in a ruggedised Pelican case for usability in the fi eld; can be powered by a 12 V supply, from a vehicle power outlet, for example as well as a standard power outlet for laboratory use; total weight is less than 40 kg.
More information online:
ilmt.co/PL/ZpJv 54035pr@reply-direct.com Instruments for Environmental and Energy Research
Environmental and Pollutant Monitoring in
Remote Locations pQA – Portable Quadrupole Analyzer
Energy Storage Research and CO2 Conversion Studies
HPR-40 DEMS – For species analysis in electrochemistry
www.hidenanalytical.com
info@hiden.co.uk
Automated Leak Analysis for Sealed Packages
LAS – Automated leak analysis for sealed packages
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