Mass Spectrometry


Benchtop Tandem Quadrupole Mass Spectrometer


Waters’ Xevo™ TQ Absolute high-performance mass spectrometer is up to 15X more sensitive for quantifying negatively ionising compounds than its predecessor and is 45% smaller and uses up to 50% less electricity and gas supply than other high-performance tandem quadrupole mass spectrometers available on the market. The Xevo TQ Absolute is designed to help pharmaceutical, food and beverage, and environmental analytical laboratories meet regulations requiring trace-level quantitative mass spectrometry analyses for a broad set of applications.


For optimal performance, Waters pairs the Xevo TQ Absolute mass spectrometer with Waters’ ACQUITY™ Premier UPLC System with MaxPeak™ HPS technology which eliminates non-specific adsorption of compounds containing phosphate and/or carboxylate groups and improves their recovery.


Together, this integrated LC-MS/MS system is designed to drive the limits of quantitation to exceptionally low levels for many applications including: quantifying regulated impurities in drug products; performing oligonucleotide bioanalytical assays; measuring concentrations of endogenous metabolites in large cohort clinical studies; quantifying residues and contaminants in food and environmental samples; measuring low-level drugs and toxicants in physiological matrices; detecting trace-level leachables from food packaging.


The Xevo TQ Absolute incorporates thoughtful design features that enable consistent and reproducible analyses, allowing labs to maintain performance and uptime for longer periods in between routine cleaning and service intervals. This is achieved with new guidance on optimal probe positioning for both sensitivity and robustness and a source shield that helps minimise source contamination by the sample matrix or mobile phase salts.


The Xevo TQ Absolute is optimised for use with the waters_connect™ software platform and is also compatible with Waters MassLynx™ mass spectrometry software. For laboratories painstakingly reviewing the results from large numbers of samples, or those quantifying hundreds of small molecule components and contaminants in a single run, the MS Quan app on waters_connect and its unique Exception Focused Review (XFR) functionality, lets scientists review data in up to half the time it used to take them.


More information online: ilmt.co/PL/4zkd 58113pr@reply-direct.com


New Atmospheric Plasma Applications Catalogue


Hiden Analytical develops and supplies instruments for a new era of analysis of ions, radicals and neutrals from high pressure plasmas. The latest in the range of application showcase brochures, Atmospheric Plasma Applications, offers an insight into the applications that Hiden’s atmospheric plasma range address.


The Hiden instruments for atmospheric plasma analysis include the HPR-60 MBMS as well as the HPR-20 R&D gas analysis range. The HPR-60 system is a specialised system, developed specifically for direct measurement of atmospheric plasma species. The HPR-20 R&D allows for real time gas analysis of neutral products from plasma, effective in plasma catalysis applications.


The range of applications highlighted include the commercial use of atmospheric plasmas for dermatology and wound healing as well as for surface modification of polymers. Novel applications include PADI (Plasma Assisted Desorption Ionisation) for the sensitive detection of explosive compounds in airline security applications. Instrument features, specific to gaining the optimal data from an application are also showcased. For example, the high mass detection capabilities of the HPR-60, allow for cluster analysis. Combined mass and energy analysis also allows researchers to fully characterise their plasma species. Systems are equipped with Hiden’s multi-level software package, offering simple control of mass spectrometer parameters and complex manipulation of data and control of external devices.


More information online: ilmt.co/PL/Oyal 57971pr@reply-direct.com


Powerful Stable Isotope Ratio Mass Spectrometer


Isotopx introduces SIRIX, a new large radius gas source stable isotope ratio mass spectrometer. SIRIX features advanced multicollector technology derived from the Phoenix Thermal Ionisation MS. It also includes the company’s unique, patented ATONA® amplifier technology in combination with a high sensitivity, high mass resolution spectrometer design. The result is a powerful, versatile, sensitive, stable isotope mass spectrometer that is intuitive to use, and can also be optimised for the most exacting applications, including the measurement of isotopologues.


Key features include: 9 individually movable Faraday detectors; lLarge 90°27 cm radius magnet; simultaneous measurement of m/z 44, 45, 46, 47, 48 and 49; wide flight tube ensures no backgrounds from reflected ions; mass resolving power of 5,000 is obtainable; better than 10 ppm


precision for 48 CO2 / 44 CO2, within 100 minutes; ATONA® allows accurate and precise measurement of ion signals of >1e-7 A down to <1e- 17 A on the Faraday array.


Users of SIRIX will also benefit from the capability to significantly increase their throughput compared to existing solution. The exceptionally quiet and stable amplifier system allows for extended measurement times of sample gas, without the need for repetitive calibration with a reference gas, or calibration of different gain resistors


Zenon Palacz, Managing Director, said: “The addition of a smarter solution for clumped isotopes is a welcome addition to our portfolio. Through direct engagement with the isotopologue community we’ve identified where traditional IRMS systems cannot meet the analytical needs and designed a solution to fill that gap. Our experience with larger radius, large magnet instruments from TIMS and noble gas analysis put us in an excellent position to provide this solution. Furthermore, our ATONA® technology lends itself incredibly well to isotopologue applications where there are large variances in isotope abundances.


More information online: ilmt.co/PL/LqjP 56966pr@reply-direct.com


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