Microscopy & Microtechniques 39 High-speed, automated inverted microscope system


Evident has launched the IXplore™ IX85, an advanced automated inverted microscope system designed to accelerate research workfl ows with unmatched speed, clarity, and precision. Featuring an industry-leading 26.5 mm fi eld number (FN) and advanced imaging tools, the system enables researchers to capture more data with greater accuracy while streamlining analysis.


The IXplore IX85 delivers consistent lighting across the entire fi eld of view, ensuring high-quality, uniform images. Proprietary distortion correction technology and expanded fl atness provide accurate sample representation, even at the edges. Intelligent Shading Correction further enhances image quality by enabling seamless, high-resolution stitched images.


A breakthrough in objective usability, the system introduces a new silicone gel pad that moves with the objective, eliminating the need for frequent oil replacement and reducing maintenance.


“With an expansive fi eld of view and advanced imaging capabilities, the IXplore IX85 enables researchers to uncover new insights faster than ever,” said Motoki Inoue, Vice President of Product Management and Marketing, Life Science Research. “Users can cover larger areas with fewer images, capture more data points per image, and signifi cantly reduce stitching time - cutting the number of required images by up to 50% compared to previous models.”


Designed to enhance lab effi ciency, the IXplore IX85 integrates automated acquisition features, real-time image processing, and customisable workfl ow interfaces. A new automatic correction collar optimises image quality by fi ne-tuning objectives to reduce spherical aberrations caused by sample variations.


“The system’s modular design ensures long-term adaptability,” Inoue added. “With dual built-in ports for multimodal setups and an open-frame architecture, researchers can easily customise and expand their system to meet evolving needs.”


Additional upgrades include environmental control and advanced imaging modalities such as Spinning Disk Confocal, Super Resolution, Total Internal Refl ection Fluorescence (TIRF), and Photomanipulation.


By delivering faster acquisition times and unparalleled imaging performance, the IXplore IX85 supports a wide range of research applications, empowering laboratories of all sizes to stay at the cutting edge of scientifi c discovery.


More information online: ilmt.co/PL/bjkY 63796pr@reply-direct.com


New integrated multimodal analytical (S)TEM for advanced materials science research


Thermo Fisher Scientifi c Inc introduced the Thermo Scientifi c™ Iliad™ (Scanning) Transmission Electron Microscope (S)TEM at the European Microscopy Congress 2024 in Copenhagen, Denmark. This groundbreaking multimodal analytical solution provides researchers with unprecedented insights into the chemical nature of advanced materials at the atomic level.


Utilising Thermo Fisher’s legacy of innovation, the Iliad (S)TEM seamlessly integrates multiple technologies into a user-friendly workfl ow.


“A platform like this only comes around once in a decade,” said David Wall, Vice President and General Manager of Materials Science at Thermo Fisher Scientifi c. “Since its unveiling at EMC, Iliad has received enthusiastic responses from researchers and industry leaders worldwide, marking the beginning of a new era in integrated microscopy technology.”


The Iliad (S)TEM features the new Thermo Fisher Scientifi c EELS Spectrometer and Energy Filter, along with the NanoPulser, an electrostatic beam blanker that optimises electron dosing. This integration of energy dispersive spectroscopy (EDS), EELS, and NanoPulser provides precise chemical and structural investigations of a wide range of modern materials.


Controlled by the Thermo Scientifi c Velox software ecosystem, Iliad enables even the most challenging experiments to be accessible for every user. Nearly all components can be accessed via Python scripting using Autoscript, allowing advanced control and AI-driven data collection strategies, ensuring reliable workfl ows.


Professor Jo Verbeeck, co-leader of Electron Microscopy for Materials Science at the University of Antwerp, collaborated on Iliad’s development with a focus on data quantifi cation. “It’s exciting to see ideas on EELS quantifi cation implemented in a product that enhances user experience and reproducibility,” said Professor Verbeeck.


With Iliad, Thermo Fisher Scientifi c is setting a new standard for advanced analytical (S)TEM technology, empowering scientists to tackle critical challenges and contribute to a healthier, cleaner, and safer world.


More information online: ilmt.co/PL/Vq6R 63486pr@reply-direct.com


AI-enhanced workfl ows for advanced cell culture research


Leica Microsystems, a leader in microscopy and scientifi c instrumentation, is proud to announce the release of the Mateo FL, an AI-driven digital fl uorescence microscope designed to enhance cell culture analysis in advanced research settings. The Mateo FL integrates transmitted light for label-free imaging with multi- channel fl uorescence and automated analysis, revolutionising how laboratories conduct downstream experiments involving cell cultures.


Following in the footsteps of its counterpart, the Mateo TL, the Mateo FL merges user-friendly operation with a sleek, modern design. It offers advanced features for comprehensive cell analysis, including multi-modal imaging capabilities, AI-powered confl uency assessments, rapid and precise cell counting, and smart measurements for evaluating transfection effi ciency. Together, the Mateo TL and FL provide researchers with versatile tools to meet diverse experimental requirements.


“Mateo FL represents a signifi cant advancement in digital microscopy, providing researchers at all levels with an intuitive solution to streamline their workfl ows and achieve immediate results,” said James O’Brien, Vice President of Life Sciences and Applied Solutions at Leica Microsystems. “This innovation helps scientists expedite their research, minimise contamination risks, and safeguard data integrity, ensuring dependable, reproducible outcomes in the lab.”


The Mateo FL is equipped with a suite of automated workfl ows that guarantee consistent results, even with complex cell culture samples. It delivers accurate cell counts in just fi ve seconds, cutting down manual counting time by an average of 15 minutes. Additionally, the new automated phase contrast feature simplifi es image acquisition, further enhancing workfl ow effi ciency.


Designed with a compact, integrated structure, the Mateo FL minimises contamination risks by over 50% and boosts workfl ow effi ciency by capturing both monochrome and color images without the need to switch devices during an experiment.


For laboratories requiring stringent data management, the Mateo FL includes built-in audit trails and user management functions, ensuring compliance with FDA 21 CFR Part 11 standards. This makes it an ideal choice for the pharmaceutical research sector, where secure data tracking is paramount.


More information online: ilmt.co/PL/LLyd 63249pr@reply-direct.com


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