Drug Discovery, Pharmaceuticals & Cannabis Testing


Flash point testing of ethanol content in cosmetic products


Insights into many unanswered questions in pharmaceutical research and vaccine development


Is the API inside the drug delivery system? How stable is this structure when changing the temperature or pH, or when stress is applied? What is the internal structure? What are the biomolecular interactions? How are nanoparticles arranged in a pharmaceutical formulation? What is the particle size, size distribution and polydispersity of a nanoparticulate drug? What is the three-dimensional structure of a protein in solution?


All of these questions, and more, can be answered by using small-angle X-ray scattering (SAXS), an advanced, non-destructive analytical technique that provides unparalleled insight into nanoscale structures. SAXS has become indispensable in the study of nanoparticles, drug delivery systems, and protein formulations, in particular due to the ability to analyse the structure of biological samples in solution, i.e. in their native state.


Ethanol content determines the fl ash point in cosmetic products. A low fl ash point can be a safety issue not only in transportation but also during production, especially in summertime. The large quantities of ethanol required for production entail a major risk if the fl ash point temperature of the cosmetic product is lower than the ambient temperature. Therefore, to limit the amount of evaporating ethanol it is sometimes necessary and good practice to reduce the ethanol content in formulations during high- temperature seasons.


ABA 500, ABA 300, TAG 500, and TAG 300 are perfectly suited for measuring fl ash points of ethanol-containing samples. The impact of small changes in ethanol concentration can be tracked closely thanks to the high precision of our Abel and TAG fl ash point testers.


The following measurements show how the fl ash point is changed by adding only a small amount of ethanol to the original products. For the tests we used three different original cosmetic products:


• Aftershave (8% ethanol content) • Skin cleaning agent (10% ethanol content) • Vitamin C serum (15% ethanol content)


The following table shows the fl ash points that were found for the:


• Original samples • Samples with 2% added ethanol


• Samples with added ethanol, taking the total ethanol content of each sample to 20%


SAXS provides insight into the size and size distribution of nanoparticles and nanosized domains, the shape of particles, the internal structure of, e.g., core-shell particles and multi-lamellar structures. SAXS also offers insights into the specifi c surface area of porous materials, the crystallinity, the orientation of anisotropic materials, and the structural changes under shear (RheoSAXS), all under varying conditions (temperature, humidity, pH, etc.).


The variety of samples for pharmaceutical applications ranges from biological samples (proteins, lipids) measured in their native environment, nanoparticle dispersions, self-assembled structures such as surfactants, emulsions (such as liposome structures used for encapsulation of vaccines or drugs), liquid crystals, with crystalline order at the nanometer scale, mesoporous materials that often exhibit large surface areas, (bio)polymers, copolymers, composites, natural and synthetic fi bers, and thin fi lms that can be measured in grazing incidence SAXS or WAXS mode.


Anton Paar’s SAXS instrumentation empowers researchers to address complex pharmaceutical challenges, paving the way for breakthroughs in drug development. For more information, visit www.anton-paar.com.


More information online: ilmt.co/PL/x5qM 63771pr@reply-direct.com


No smoke, just results: Streamlined CBD testing with FTIR


Fourier Transform Infrared (FTIR) spectroscopy offers a fast and effi cient alternative to traditional methods such as High-Performance Liquid Chromatography (HPLC) for quantifying cannabidiol (CBD) in cannabis oils. FTIR spectroscopy simplifi es the process and provides rapid results with suffi cient precision for routine quality control.


Using an Attenuated Total Refl ectance (ATR) accessory, FTIR spectrometers measure the absorbance of specifi c infrared peaks that directly correlate with CBD content. ATR technology enables direct analysis of liquid samples, requiring minimal sample preparation as the oil can be applied directly onto the ATR crystal without dilution or additional chemical reagents. This reduces preparation time and eliminates the risk of introducing errors during sample handling. These


measurements allow the creation of accurate calibration models covering a wide range of CBD concentrations, ensuring reproducible results for various cannabis oil samples.


The Lyza 7000 FTIR spectrometer from Anton Paar optimises the process for maximum effi ciency. With its guided fi ve-step quantifi cation feature, the instrument simplifi es workfl ows, making CBD analysis straightforward. Producers benefi t from fast, consistent data generation without the need for extensive chemical reagents or complex preparatory steps.


This streamlined approach enables cannabis oil producers to verify product quality and consistency quickly and effectively.


For detailed insights into Lyza 7000’s application in cannabis oil analysis and to access the full application report, visit the website or get in contact today.


More information online: ilmt.co/PL/z5lJ 63770pr@reply-direct.com Redefi ning tap density testing with durability, precision, and compliance


Anton Paar’s Ultratap 500 series sets new benchmarks in tap density testing. Designed for durability, precision, and compliance, these instruments guarantee up to 25 million taps without calibration loss. With a robust three-year warranty, the Ultratap 500 series offers reliable and consistent performance, ensuring confi dence in results for years to come.


The Ultratap 500 series is engineered to meet all major industry standards, including USP 616 methods 1, 2, and 3, as well as 24 pre-stored ASTM, ISO, and USP methods. This ensures seamless integration into workfl ows across diverse industries. Advanced features such as automated drop height detection and integrated user management improve compliance while reducing operator errors, delivering consistent and reproducible results.


Flash point tests were conducted with ABA 500 and the standard ISO 13736 test kit. Test kits with reduced sample volume are available for the ABA X00.


The test result is the barometric pressure corrected temperature.


More information online: ilmt.co/PL/0y0J 63768pr@reply-direct.com


User comfort is a key focus of the Ultratap 500 series. It operates at noise levels 90% lower than competing models, comparable to common household appliances. For laboratories seeking even quieter operations, an optional noise reduction cabinet is available. Additional features include unmatched durability, ease of use with TruLock straps for quick and secure cylinder setup, and a responsive touchscreen that simplifi es access to pre-stored and custom methods. Automated reporting capabilities provide accurate measurements of bulk density, Carr’s Index, and Hausner Ratio, ensuring comprehensive and reproducible data.


Ideal for pharmaceutical, chemical, and other material testing applications, the Ultratap 500 series combines advanced hardware and intuitive software for accurate, reliable results. This makes it an indispensable tool for laboratories that require precise tap density analysis.


More information online: ilmt.co/PL/1ye8 63769pr@reply-direct.com


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