6 Direct adaptive HPLC column connectors
When changing from a Waters column to another brand like an Agilent Column, do you find changing the ferrules and tubing (to maintain data integrity) time consuming? If so, Microsolv Technology Corporation have a solution that can help, introducing the MicroSolv™ Direct Adaptive (Di-Ad™) HPLC Column Connecters. They make this process much faster and easier without fussing with ferrules and tubing between column changes.
These Direct Adaptive Fittings were designed for you to avoid poor column connections and eliminate extra system volume. The universal pilot length of this spring-loaded connector adapts to any HPLC column for quick column swaps and prevention of poor connections that cause peak broadening. Available as a Single End Fitting or a Double End Fitting. You just simply screw the Di-Ad™ fittings into the column and the tubing pilot length will automatically be adjusted.
More information online:
ilmt.co/PL/Ey50 57858pr@reply-direct.com
AI-Powered autosampler revolutionises laboratory workflow
HTA unveils the 2800T, an innovative all-in-one autosampler harnessing the power of Artificial Intelligence (AI). This ground-breaking technology autonomously handles headspace analysis, liquid sample injection, and Solid Phase Microextraction (SPME) within any GC and GC-MS system.
Building upon the success of the GC automatic liquid samplers (3000A series) and headspace autosamplers (2000H series), HTA has integrated the disruptive capabilities of AI into the multifunctional 2800T autosampler.
The incorporation of smart AI functionalities delivers substantial benefits to analytical laboratories in terms of efficiency, speed, and reliability. AI-powered features streamline laboratory workflows and simplify sample processing. Continuous and automatic monitoring of all components and consumables, extending beyond the autosampler to include the GC, ensures trouble-free operations and provides the assurance of consistent and reliable results through predictive maintenance practices. From enhancing analytical performance to improving user-friendliness and technical service accessibility, AI simplifies every aspect of the process.
Regarding application flexibility, the 2800T features the most versatile profile on the market. Transitioning between modalities takes a mere 5 minutes, and it’s just as quick to switch between GC instruments. In less than 5 minutes, you can effortlessly relocate the HTA autosampler from one GC to another, swap HTA autosamplers, or allocate a single HTA autosampler across multiple GCs to handle workload surges. Whether your samples require headspace, liquid, or SPME processing, or if your method demands split, splitless, or on-column injection, the 2800T is ready in minutes.
its comprehensive GC automation capabilities, the 2800T is exceptionally user-friendly. The high-quality touchscreen interface provides effortless system access and usability, enabling sample processing with a simple touch.
Once again, HTA empowers analytical labs to stay at the forefront of technology. More information online:
ilmt.co/PL/wv5O
61216pr@reply-direct.com
Advanced degassing solutions for GPC applications
Biotech Fluidics has unveiled two cutting-edge degassers optimised for Gel Permeation Chromatography (GPC) applications: the DEGASi Plus GPC and DEGASi Plus GPC Semi-Prep.
In liquid chromatography systems, changes in pressure or temperature can lead to the formation of gas bubbles, potentially impacting accuracy and equipment performance. Online degassing is a trusted method for removing dissolved gases from the fluid stream, effectively preventing bubble formation, reducing noise, and enhancing baseline stability, thus ensuring more consistent results. However, traditional degassers often struggle to handle GPC applications utilising 100% organic solvents.
To address this challenge, Biotech Fluidics developed the DEGASi Plus GPC and DEGASi Plus GPC Semi-Prep. These exceptional high-performance degassers are compatible with a wide range of organic solvents, including hexane and chlorinated solvents, thanks to their robust degasser membrane. This internal connection within the fluidic line is essential for efficient degassing in GPC and straight phase separations using 100% organic solvents.
Operating nearly silently, the user-friendly DEGASi Plus GPC and DEGASi Plus GPC Semi-Prep require minimal bench space and are fully compatible with all commercial GPC/SEC systems. The DEGASi Plus GPC, available in 1-6 channels, employs continuous vacuum system monitoring to maintain optimal operational conditions. Additionally, Biotech Fluidics has integrated advanced error and leak checking functions, along with their patented ZHCR® to eliminate baseline fluctuations.
With an exceptionally chemical-compatible flow path, this CE and RoHS compliant unit is designed for trouble-free operation, even in continuous 24/7 usage spanning over 5 years. More information online:
ilmt.co/PL/38lK
61461pr@reply-direct.com control
New technical note demonstrates high temperature stability of resins
Ion exchange chromatography (IEX) is a well-established method for the purification of biomolecules. The optimisation of the used method is very important to maximise the process productivity. YMC’s BioPro IEX SmartSep resins can be used up to 60°C - offering great flexibility in method development. This is particularly advantageous for the purification of oligonucleotides.
The examples shown in the Technical Note point demonstrate the extended temperature stability of the BioPro IEX SmartSep resins. In a first example, the BioPro IEX SmartSep S20 and Q20 resins were flushed with a buffer at 60°C for 20 hours. The column performance test showed no retention time shift for the proteins investigated – even after repeating the procedure for 5 times. Furthermore, no change in the separation or peak distortion could be observed for BioPro IEX SmartSep Q and S resins even after 100 hours of exposure to a 60°C solution.
Even under more practical conditions for the purification of oligonucleotides the BioPro IEX SmartSep Q resin maintained its performance. The elution profile of an antisense oligonucleotide remained constant even after eluting the column at 60°C for 130 runs. There is no retention time shift, and the column efficiency remains the same.
These experiments demonstrate the excellent temperature stability of the BioPro IEX SmartSep resins. The resins maintain their performance when used with higher eluent temperatures. This can be useful for many applications such as oligonucleotide purifications and offer a greater flexibility in method development.
Find all these useful information about high temperature stability of BioPro IEX SmartSep resin in this Technical Note. More information online:
ilmt.co/PL/mVzm 61054pr@reply-direct.com
LAB ASIA - DECEMBER 2023
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44
