16 Single-Cell Picker for Mass Spectrometric Analysis of Single Cells
iotaSciences, the Oxford-based leader in the rapidly growing field of single-cell handling solutions, announced today the first encouraging data for the use of its recently launched single-cell picking instrumentation isoPick™ based on the company´s proprietary fluid-shaping technology. In a collaboration with SEISMIC at the University of Surrey, the isoPick™ has been evaluated for single-cell sampling for subsequent analysis by mass spectrometry. Notably, the isoPick™ came out strongly against several aspects related to ease of use, portability and automation. The results of the evaluation study were presented as a poster presentation at the British Mass Spectrometry Society (BMSS) annual meeting in Manchester from 12-14 September 2023.
Professor Melanie Bailey from the Department of Chemistry at the University of Surrey said: “We have been pleased with the recent comparative performance of the isoPick™ instrument in our attempt to develop methods for mass spectrometry-based analysis of single cells. We look forward to further collaboration with iotaSciences while we develop a facility for single-cell and sub-cellular “omics” and to support UK academics and industry researchers working in BBSRC (Biotechnology and Biological Sciences Research Council) remit areas.”
IotaSciences’ Chief Product Officer Alexander Feuerborn commented: “We are extremely excited about this first encouraging set of data for the isoPick™ instrument for mass spectrometric analysis of single cells. These results strongly confirm our original intentions to introduce a high-quality, precise and robust single-cell picking instrument with an easy-to-use end-to-end solution for verifiable isolation and subsequent analysis of single cells. For us, this clearly opens the wider application space in the fields of single-cell proteomics and lipidomics.”
More information online:
ilmt.co/PL/E35l 61194pr@reply-direct.com Comprehensive Raman Library for Material Identification
Metrohm is pleased to introduce its latest innovation, the Metrohm Comprehensive Raman Library. This comprehensive resource contains an impressive collection of over 16,200 substances, simplifying material identification across a wide range of industries. The library significantly enhances the capabilities of handheld and laboratory Raman systems.
Derived from the strong foundation of the Illicit and Common Materials Library and the USP Certified Compounds Library, this Raman library stands as one of the most extensive collections of Raman spectra available today. It has been optimised for use with Metrohm’s MIRA XTR DS and MIRA P instruments, as well as B&W Tek’s TacticID and i-Raman instruments.
Metrohm gathered substances from around the world and meticulously constructed this library using state-of-the-art Metrohm instruments, ensuring the highest levels of quality and precision. The result is exceptional accuracy across the entire Raman portfolio, encompassing both handheld and laboratory systems operating at 532, 785, and 1064 nm wavelengths. This includes spectra collected using Metrohm’s cutting-edge XTR fluorescence suppression algorithm.
The Metrohm Comprehensive Raman Library comprises over: 7,000 organic chemicals; 2,250 inorganic/organometallic compounds; 1,900 polymers and plastics; 1,700 personal care products; 150 dyes, paints, and pigments.
Beyond being a vast collection of spectra, the library includes vital metadata such as compound characteristics, physical properties, and crucial safety information. Metrohm is committed to ongoing library development and plans to provide regular library and software updates.
“Metrohm built this library from the ground up with the goal to make the largest and most meaningful library for all of our customers,” said Nancy Morris, CEO of Metrohm Spectro. “The work continues, so we can offer the most complete and effective Raman experience possible.”
More information online:
ilmt.co/PL/6qDo 61294pr@reply-direct.com Monitoring Non-Metallic Inclusions in Steel Manufacturing
Thermo Fisher Scientific has unveiled the Thermo Scientific™ ARL iSpark™ 8860 Inclusion Analyzer with Spark-DAT, the latest addition to its ARL iSpark Series Optical Emission Spectrometers. This advanced analyser offers a unique combination of full elemental analysis and rapid characterisation of non-metallic inclusions in steel, allowing steel manufacturers to ensure low inclusion levels during production, preventing issues like nozzle clogging in continuous casting processes.
The ARL iSpark 8860 is the first optical emission spectrometer capable of simultaneously providing full elemental coverage and detailed information on non- metallic inclusions in a single analysis. It identifies and quantifies inclusion features, such as type, number, size, concentration, and volume fraction, enabling real-time control over inclusion content in steel products. This, in turn, helps prevent costly production problems and ensures the mechanical properties of the final products meet the desired standards, reducing the risk of customer claims or product returns.
The ARL iSpark 8860 Inclusion Analyzer from is equipped to conduct advanced elemental analysis and provide comprehensive inclusion data for steel. It incorporates 1m vacuum Paschen-Runge optics featuring photomultiplier tube (PMT) detectors and ensures full elemental coverage, encompassing even gas elements. This analyser delivers ultra-fast inclusion analysis and includes a suite of comprehensive inclusion analysis software tools such as Spark Explorer, Inclusions Report, and Statistical Process Control (SPC). Users have the flexibility to customise inclusion analysis methods and receive expert training from Thermo Fisher Scientific. Furthermore, the system can be easily automated using the ARL Sample Manipulation System (SMS), enhancing efficiency in steel manufacturing processes.
More information online:
ilmt.co/PL/beVG 61181pr@reply-direct.com Enhancing SPR Instrument Performance
Biotech Fluidics AB has announced its partnership with BioNavis Oy, wherein it will provide essential microfluidic and degassing components for BioNavis Oy’s Multi-Parametric Surface Plasmon Resonance (MP-SPR) instruments.
Surface Plasmon Resonance (SPR) has emerged as the primary technique for measuring molecular interactions in various fluidic environments, including serum, saliva, and organic solvents. Its label- free nature eliminates the need for labelling molecules, making it a highly advantageous method for evaluating affinity and kinetics of binding reactions. With the BioNavis Navi™ range of advanced Multi-Parametric Surface Plasmon Resonance (MP-SPR) instruments, researchers gain access to exceptional features and performance that enable in-depth studies of surface interactions and nanolayer characterisation.
The Navi MP-SPR instruments provided by BioNavis facilitate crucial scientific investigations, such as antibody characterisation, exploration of drug uptake pathways, controlled drug release strategies, precise measurements of small molecules, targeted delivery of nanoparticles, and even drug internalisation by living cells.
Jussi Tuppurainen, Technical Director of BioNavis commented: “The key part of our MP-SPR fluidics systems are IDEX port selection valves supplied by Biotech Fluidics. These high-quality valves contribute to precise handling of samples, allowing researchers to control the timing, volume, and flow rate of injected liquids. This precision is vital for achieving reproducible results and minimising variations in sample concentration. Additionally, the Degasser system supplied by Biotech Fluidics helps maintain sample integrity by preventing the introduction of air bubbles, which can disrupt measurements. Careful fluidic design and efficient degassing techniques eliminate bubbles and preserve the stability of the sample, ensuring reliable data.”
In conclusion, Jussi Tuppurainen said: “BioNavis has been a satisfied customer of Biotech Fluidics for many years. We highly recommend them not only for their top-quality products, but also because of the consistently professional and friendly customer service they provide.”
View or download the catalogue containing fluidic components for SPR instruments:
ilmt.co/PL/k8GE More information online:
ilmt.co/PL/Qe0y
60809pr@reply-direct.com
INTERNATIONAL LABMATE - NOVEMBER 2023
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