2 February / March 2019 Foreword
Welcome to a brand-new year at Chromatography Today and the first edition of 2019. Last year was another great year for Chromatography Today with our buyers’ guide - now an annual feature, a growing readership and an increase in submitted articles. To keep the articles and features fresh and topical for 2019 we will retain the two general themes throughout the year - Fundamental Aspects of Chromatography and Modern Chromatography Applications to provide you with both advances in the fundamental aspects, method development and new instrumentation in analytical separation science and modern cutting edge and practical applications of analytical separation. The focus areas within these two themes for this edition are ‘Electrophoretic separations/CE/CE-MS’ and ‘Agricultural Analysis’ respectively. These two themes will be separated by the Chromatography Today Knowledgebase which covers the role of methanol and acetonitrile as organic modifiers in reversed-phase liquid chromatography.
Trevor Hopkins - Editor
In the current issue for the Electrophoretic separations/CE/CE-MS focus area, we present an article by Chromatography Today Editorial Board member Gerard Rozing which provides the background, current status, and perspectives of imaged Capillary Iso-Electric Focusing (iCIEF). This article is a great lead in to an article by Tiemin Huang
et.al. which focuses on achieving high-throughput precision with on-board mixing for iCIEF. Further contributions by Rawi Ramautar of Leiden University, the Netherlands who explores the possibilities of capillary electrophoresis-mass spectrometry (CE-MS) for metabolic profiling and Alexander Stoyanov from the University of Missouri, School of Medicine, Columbia MO, USA who considers a chromatography and Isoelectric Focusing and Mass Spectrometry approach to the A1c test for individual variabilities in haemoglobin glycation. Hyphenated MS based approaches for A1c quantitation provide an opportunity of considering the individual variabilities in haemoglobin glycation that potentially allows for a personalised approach to diabetes patients.
This issue also has three off-topic articles which have been submitted by the authors - the first by Terry Berger of SFC Solutions, Inc Florida, USA clarifies the relationship between density and viscosity of methanol/carbon dioxide mixtures used in Supercritical Fluid Chromatography and outlines why changes in viscosity, not density, explains both pressure drops and changes in diffusion coefficients with pressure and modifier concentration. This is counter to most of the recent SFC literature recommendations which stress relationships between density and retention. The second off-topic article is by Professor Fred Regnier, who will be one of the plenary speakers at the 2019 ISCC GCxGC symposium in Ft. Worth, May 2019, who covered the novel and interesting topic of Analyte-Sequestering Transport Phases as a new dimension in LC. The final of these off- topic articles is by Richard Verseput of S-Matrix who discusses the integration of MS and UV data in QbD pharmaceutical method development.
The ‘Agricultural Analysis’ focus area covers the challenges of sample matrix effects with an article by Zaharie Moldovan from the National Institute of Research and Development for Isotopic and Molecular Technology, Cluj, Romania entitled the characterisation of organic compounds in aquatic sediment from the Somes River catchment, Romania by ion profiles obtained using GC/MS system. The second article by Gesa Schad of Shimadzu discusses the analysis of high levels of melamine discovered as a by-product in some calcium cyanamide hydrate products which is employed as a multipurpose nitrogen fertiliser.
The next issue of Chromatography Today will be focusing on Ambient ionisation techniques for MS and Novel petroleum and petrochemical applications. Each edition of Chromatography Today is packed with valuable information, however it is impossible to include everything that is submitted. The new revised Chromatography Today website (
www.chromatographytoday.com) is the repository where you will find the other submissions, the latest news from the world of separation science and access to all the historical articles. Perusing the trending news and article sections, it is surprising how much separation science plays a part in daily life without us ever appreciating it, or even realising it. There is a diverse range of areas highlighting just how important separation science is to society with a calendar of events and articles on food, biofuels, medicine, forensics, brewing and environmental clean-up. Please take a look and if you are not a current recipient of the Chromatography Today ebulletin - please sign up today.
As always, we welcome article submissions, topic ideas for inclusion in future issues and feedback from our readership. If you have any feedback on this edition of Chromatography Today, please contact us as we are always looking to improve the publication.
Trevor. Next Issue -
Fundamental Aspects - Ambient Ionization techniques for MS Modern & Practical Applications - Novel petroleum and petrochemical applications
To be included call us on +44(0)1727 855574 or
info@chromatographytoday.com
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