Laboratory Products 21
Molecular Test for Rapid and Accurate Detection of Carbapenemase-Producing Gram-Negative Bacteria Released in Europe Cepheid has announced the release of Xpert®
Carba-R, an on-demand molecular test for rapid and accurate detection of carbapenemase-producing
Gram-negative bacteria, to be marketed as a CE IVD product under the European Directive on In Vitro Diagnostic Medical Devices. The test runs on Cepheid’s GeneXpert®
System, the world’s leading molecular diagnostic platform. Xpert Carba-R detects and differentiates genes encoding the most prevalent carbapenemases, reporting five gene families that comprise 68 known individual resistance genes, including KPC, NDM, VIM, OXA-48 and IMP-1.
“Carbapenemase-producing organisms were named for their ability to fight off carbapenem antibiotics, the last line of defence in our medical toolbox,” said John Bishop, Cepheid’s Chairman and CEO. “Xpert Carba-R provides healthcare institutions a much needed tool for rapid and accurate detection of patients colonised with these multidrug resistant organisms to help prevent widespread outbreaks and determine the best infection prevention pathways.”
“Detection of patients carrying carbapenemase-producing microorganisms, with differentiation among the five major families of resistance genes, can significantly impact infection control. With results in less than an hour, we have the advantage of rapid implementation of epidemiological measures to control the spread of these microorganisms,” said Dr Rafael Cantón, Professor of Microbiology at the Hospital Universitario Ramón y Cajal, Madrid, Spain.
Carbapenemases of global importance include Klebsiella pneumonia carbapenemase (KPC), New Delhi metallo-ß-lactamase (NDM), Verona integron-encoded metallo-ß-lactamase (VIM), imipenemase metallo-ß-lactamase (IMP), and oxacillinase-48 (OXA-48). As of 2014, KPC is the most widespread carbapenemase in the United States while OXA-48 is becoming the most important one in most European countries.
“Like our other GeneXpert cartridges, Xpert Carba-R can be performed on a STAT basis — no waiting for batched results. Rapid identification of colonised patients allows healthcare institutions to begin immediate implementation of infection control measures to prevent spread in highly susceptible populations,” said David Persing, MD, PhD, Cepheid’s Chief Medical and Technology Officer. “Active screening of high risk patients has the additional benefit of allowing clinicians to optimise isolation decisions and avoid the impact of unnecessary isolations.”
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New RAININ 2014/2015 Catalogue Now Available
The new RAININ 2014/15 catalogue is now available from Anachem. Request your free copy to find out about all the latest products and services available to help you in your lab.
This new catalogue is the ideal whenever you’re in need of new or additional pipettes, tips or lab equipment. It is packed full with technical information about the wide range of products available, including the new family of XLS+ pipettes, BioClean pipette tips and the new Low Volume Liquidator 96 plus much more. Just flick through to find out all the technical and ordering information you need to help make your purchasing decision.
To request your free Rainin catalogue simply email
marketing@anachem.co.uk and supply your full name and address. Alternatively go to
www.anachem.co.uk/ technicaldocuments and download the PDF file.
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World’s first Phosphorus-31 Capable Benchtop NMR Spectroscopy System Announced
Magritek, a leading provider of compact NMR and MRI instruments, is pleased to announce the Spinsolve Phosphorus, the world’s first Phosphorus-31 capable benchtop NMR spectroscopy system.
Phosphorus is commonly found in many organic compounds, for example in biological membranes or DNA. The 31P nucleus has a 100% natural isotopic abundance and a large chemical shift range, making it one of the most commonly used nuclei in biological NMR. For the first time users can have the power of proton-phosphorus NMR in a benchtop instrument that can be safely used in the laboratory.
The launch of Spinsolve Phosphorus adds a new member to the successful Spinsolve family of benchtop NMR spectrometers. It has been designed to meet the needs of several groups of users: pharmaceutical and medicinal chemists, synthetic chemists monitoring reactions, industrial chemists measuring purity of their compounds, academics focused on organic chemistry education and researchers or post graduate students doing small molecule structure elucidation.
To meet the requirements of these users, Magritek have produced a comprehensive list of features designed to deliver cost efficient benefits to all. Spinsolve Phosphorus offers users 1D 1H, 19F and 31P experiments that use standard 5 mm NMR tubes. 31P can be acquired with or without proton decoupling. Proton 2D COSY and homonuclear j-resolved spectroscopy are offered along with T1 and T2 relaxation experiments.
Due to its large chemical shift range, the absence of impurities in the background spectrum, and the single NMR peak, 31P is used routinely for both purity assessment and reaction monitoring. Databases of 31P chemical shifts are used routinely and isomers are easily identified.
The powerful, yet easy to use software aids to the simplicity of Spinsolve Phosphorus. Uncomplicated one-button operation with a minimum amount of user controlled parameters coupled to an intuitive graphical interface means the system can easily be operated by anyone from students to experienced research chemists. For reaction monitoring applications, the system may be automated and integrates closely with the industry leading MNova data processing software from Mestrelab. The traditional NMR complexities are hidden and automated which make using a Spinsolve a short and pain-free learning experience while delivering research-grade results.
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Dr Peter Dunstan is an Associate Professor in the Department of Physics at Swansea University and a member of the University’s Centre for Nanohealth. His research utilises state of the art techniques and instrumentation to increase the fundamental understanding of the structural, chemical, optical and electronic properties of materials on the nanoscale, and by doing so advance the future application of those materials.
Asked why AFM is an important technique in his research, Dr Dunstan said: “AFM based systems give us the opportunity of generating a clear understanding of the structure of the materials that we investigate. AFM can also offer us the opportunity to correlate this structural measurement with other characteristics. For instance, by coating an AFM probe with gold and utilising the interaction between the metallised tip and a sample, it allows us to exploit an optical antenna effect when the tip is illuminated by an externally focussed laser of a suitable wavelength. This arrangement allows us to simultaneously correlate an enhanced localised spectroscopic response from the sample, along with the normal AFM response, and in doing so advance the application of the AFM instrument in line with our research objectives.”
Dr Dunstan is well placed to comment on the advantages he sees in the NanoWizard®
system. “One major aspect of the
benefits of using JPK has been their ability to embrace our own research innovations and hence allow us to integrate our technology advances into the JPK instrument. This has allowed us to retain the advances we have made and integrate them onto the stable JPK AFM platform for improved performance. Also partnership with other companies has been important and is an area where JPK showed tremendous willing for cross- platform integration. Most recently, we published a paper in the Journal of Raman Spectroscopy on the use of TERS, tip-enhanced Raman spectroscopy, where we combined our JPK AFM and Renishaw Raman spectrometer to enhance lattice defect signatures in graphene.”
”It is important to mention we have benefited from the keen commitment of JPK staff to help us develop specialised adapted software approaches for our instrument when performing tip- enhanced spectroscopies and this has allowed us the precise control in the acquisition parameters that we require.”
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Report on AFM System use to Study the Properties of Materials on the Nanoscale
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