6 Launch of New Cryo-Correlative Cooling Stage
Linkam are pleased to announce the development and launch of a stage for cryo-correlative light/electron microscopy (cryo-CLEM). It was designed in collaboration with scientists at the Leiden University Medical Centre (LUMC) led by Bram Koster and Erik Bos. Cryo-CLEM is the correlation of images captured with a cryostage on a fluorescent light microscope and images of the same sample observed with Transmission Electron Microscopy (TEM).
Dr Lucy Collinson of the London Research Institute (LRI) and Cancer Research UK (CRUK), is using the correlative stage as part of a workflow that starts with cells expressing cancer-related genes and ends with imaging in synchrotrons located in Oxford, Berlin, and Barcelona. Within the synchrotrons, the scientists are able to image the cells using a cutting-edge technique called 'soft X-ray tomography'. The LRI focuses on three themes of research: the biology of tissues and tumours, cellular regulatory mechanisms and genomic integrity & cell cycle.
The correlative stage can hold samples at a stable -196°C enabling scientists to study TEM grid samples at 100x magnification, identifying areas of further interest, and facilitating the movement of these analysed grids to the TEM. With automated liquid nitrogen control, heated optics and a digital display the unit is a compact and efficient system for this work.
In particular, Dr Collinson is working with Dr Sharon Tooze, Head of the Secretory Pathways Laboratory at the LRI, to study cells that are undergoing autophagy, which is a normal process involving degradation and recycling of unnecessary or dysfunctional cell components
With Dr Liz Duke, a Principal Beamline Scientist at the Diamond Light Source synchrotron in Oxfordshire, they have developed a process for imaging these fluorescent proteins in cells as close to their living state as possible, considering that they must place them in a vacuum to take very high magnification images. They grow the cells on very thin carbon films attached to a 3mm diameter gold grid and freeze the cells in liquid ethane at –174°C.
The correlative stage is used to image the fluorescence in the cells while they are still frozen. The frozen grids are then shipped to the synchrotron, where they put them into the soft X-ray microscope so that they can image the structure of the entire cell in 3D.
MICROSCOPY MORE INFO. 520
High Throughput Haematology Analyser Launched
Stability/Degradation Testing System with Superior Control for Improved Analysis
Chemical Stability, Forced Degradation, Stress Testing are just some of the applications for the Amebis Stability Testing and Monitoring System (STAMS) available from ATG Scientific.
This highly flexible, low cost tool with 21 CFR part 11 compliant software is for any laboratory or research facility with interests in drug discovery, analytical chemistry, QC, formulation development and finished product.
It uses the very latest wireless technology to provide highly accurate and flexible stability testing solutions. Any condition between 0-80ºC/5-95% RH can be generated for routine or investigative studies with full data logging of the humidity and temperature readings for each sample. The system can also be used to monitor and map environmental conditions in existing stability cabinets and rooms.
LAB PRODUCTS MORE INFO. 521
Horiba Medical has launched an advanced high throughput haematology analyser, the Pentra DX Nexus. The new bench-top analyser offers reliability, efficiency and quality, combined with enhanced ease of use and reduced environmental footprint. Offering 50 parameters and a throughput of 120 samples per hour, the Pentra DX Nexus is compatible with Haemcell, Horiba Medical’s integrated laboratory solution. Its functionality is further enhanced by accompanying new features of the ABX Pentra ML data manager and an optional combination with SPS evolution slide maker/stainer.
As well as providing rapid analysis and meeting laboratory needs for precision and productivity, the Pentra DX Nexus has been designed with ergonomics in mind. The large, colour touch-screen of the integrated computer has a virtual keyboard and intuitive software. In addition, multiple USB ports enable easy data transfer and hardware connections.
Satisfying accreditation requirements, a novel feature is its ability to display information related to every sample run. A pop-up window on the data manager displays: identification; lot number; the expiry date of reagents and controls; as well as the status of quality control at the time of every result. The innovative features on the data manager include rules to provide the operator with advice based directly on ISLH guidelines and enhanced remote access with patient ID protection.
The Pentra DX Nexus has many areas of technological development that not only enhance sample handling and instrument reliability, but also bring benefits to the laboratory environment. For example, the new laser source offers reduced heat and noise output and power consumption, requires minimal space, yet delivers improved and additional parameters. Additional sample racks offered on the instrument are also compatible with most pre- and post-analytical systems available today.
“Resulting from nearly 30 years of understanding and meeting our customers’ individual needs, we hold a wealth of expertise in haematology within our team. Consequently, Horiba Medical has become a well-respected and renowned specialist in the design and manufacture of automated in vitro diagnostic systems for haematology and chemistry analysis,” said Cleve Wright, UK General Manager of Horiba Medical.
LAB PRODUCTS MORE INFO. 522
Cholesterol Testing System Accepted by UK Heart Charity for the NHS Health Check Programme
BHR Pharmaceuticals Ltd, a market leading provider of point of care diagnostics into the UK healthcare market, have announced that HEART UK, the cholesterol Charity, have accepted that CardioChek may be used as a point-of-care system for lipid testing in the community for screening proactively for heart disease.
CardioChek proves itself as an accurate, reliable and valued cholesterol testing system for use throughout the UK in the screening for heart disease, validating over 5000 systems in use in the UK primary care setting.
“2012 is a very significant year in BHR’s 22 year history. Despite the challenging global economic environment, we have achieved a consistent increase in sales demonstrating the continued strong demand for the CardioChek point-of-care test system. As the Department of Health step up the significance of the ‘Health-Check’ programme, in their drive to reduce the incidence of heart disease, the need for reliable lipid testing systems for use in primary care grows,” said Ramesh Patel, MD, and commented that “he was delighted that HEART UK had reviewed the latest validation data of the CardioChek, and noted that it was suitable for use as a community screening tool. This in turn would increase interest from primary care organisations, with a partnered approach to achieving the screening numbers in England.” Ramesh continued: “This news, together with our achievements this year represent BHR’s commitment to strengthen our leadership in point-of-care cholesterol testing and build on our already strong momentum in the healthcare and wellness industry.”
Jules Payne, HEART UK’s Chief Executive added: “HEART UK recognise the importance of the NHS health checks programme in identifying people at increased risk of heart disease. Point-of-care testing is a useful screening tool enabling patients and healthcare professionals instant feedback on cholesterol levels. Raised cholesterol is one of the greatest modifiable risk factors for heart disease which is still the biggest killer in the UK. People over the age of 40 should have their cholesterol tested. People who have a first degree relative with premature heart disease should consult their GP for a full blood test.”
LAB PRODUCTS MORE INFO. 523
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