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Head Office International Labmate Limited. Oak Court Business Centre, Sandridge Park, PortersWood St Albans, Herts AL3 6PH, UK


ISSN: 1752-8070


Contents Articles


3


Tel: +44 (0)1727 855574 Fax: +44 (0)1727 833014 info@intlabmate.com www.chromatographytoday.com


Michael Pattison, Chairman International Labmate Limited.


Sales and Marketing Bernie Monaghan, Editor Chromatography Consulting International Tel: +44 (0)1695 51973 bm@chromatographyconsulting.com


Chris Jarvis, John Hobbs-Morris and Twan Heesakkers International Labmate Sales Team Tel: +44 (0)1727 855574


Contributing Editors Alan Handley President of the Chromatographic Society alan.handley@lgc.co.uk


Dr John Lough Reader in Pharmaceutical Analysis University of Sunderland john.lough@sunderland.ac.uk


Dr Paul Ferguson Senior Principal Scientist Pfizer Global Research and Development


Richard Houghton Principal Scientist Bioanalytical Sciences, Quotient Bioresearch


Dr. John Reilly Research Investigator II Novartis Institute of Biomedical Sciences


Production Team


Helen Sweetland, ILM designs helen@ilmdesigns.co.uk


Jill Mitchell, ILM designs jill@ilmdesigns.co.uk


Gary Durham, Robert Battell, Heather Vincent, Caroline Belt and Matt Cook Published – February/March, May/June,


August/September and November/December Chromatography Today is distributed free of charge to scientists,


laboratory technicians and environmentalists throughout the United Kingdom. The publication has the support of leading suppliers of


equipment in the region and is displayed at the major exhibitions and conferences in these markets to attract additional readership.


Chromatography Today is published with the full support of the Chromatographic Society.


If you are not receiving your own copy of Chromatography Today


please send us an email with your details to info@intlabmate.com. If you are based outside of the United Kingdom a subscription charge of £55.00, €71.00 or $105.00 would apply.


Although every effort is made to ensure the accuracy of the


material published, ILMdesigns and its offices cannot accept responsibility for claims made by contributors, manufacturers or advertisers.


© All rights reserved by ILM designs reproduction in part of whole without written permission is strictly prohibited


Published with the full support of the Chromatographic Society by International Labmate (ILM)


Printed in the UK by Print House Ltd 46


Chromatographic Society Meetings Round-Up Advances in High Resolution and High Speed Separations


48 Separation Science / Spectroscopy Meetings Calender 42


Chromatography Today talks to RogerM. Smith, Chromatographic Society JubileeMedallist 2008


36


Oligonucleotides: The Next Big Challenge For Analytical Chemistry Chromatographic Society SymposiumatGSKWare


33 30 22 26 8 14


2 Foreword by Alan Handley


High temperature liquid chromatography – a brief review about an emerging technique


Fundamental issues in the implementation of a two-dimensional LCxLC separation


The Use of Temperature forMethod Development in LC


18


Turning on the Heat in Liquid Chromatography


Using GC-MS/MS for Superior Sensitivity, Specificity and Precision in Free Testosterone Analysis


Fromcrude samples to highly pure isolated solids in 4 hours


Delivery of pure, dry, free flowing solids by a customer focused,medicinal chemistry purification service, using a Lean Sigma approach


Application of dynamic temperature gradients and profiles for capillary LC through the application of a new thermoelectric array based column heater


Analysing crystalline polymers by gel permeation chromatography at high temperature


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