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The infl ammation and oxidative stress from these conditions can cause excess accu- mulation of fat in the liver. Certain medi- cations can also cause NAFLD, including corticosteroids, Methotrexate, Tamoxifen, and Tetracycline. NAFLD can progress to NASH (nonalcoholic steatohepatitis, or liver infl ammation), liver fi brosis (scarring), cirrhosis (cell degeneration, infl ammation, and fi brous thickening of tissue; typically results from alcoholism or hepatitis), liver cancer, and liver failure/premature death. Even worse, NAFLD is the precursor to many chronic diseases, including heart dis- ease, dementia, autoimmune disorders, hy- pothyroidism, and sleep and skin problems. In most cases of NAFLD, improved insulin sensitivity is the main goal, and weight loss is its most effective treatment. The balance of this article primarily addresses measures that promote the fl ow of fat and bile to and from the liver, which can benefi t all NAFLD patients, whether or not overweight.
A Liver-Supportive Diet & Lifestyle Due to the connection of NAFLD
to infl ammation, oxidative stress, and obesity, it can be highly responsive to diet and lifestyle changes. Dietary changes generally include: (1) eliminating high- glycemic/high-sugar (refi ned carbohy- drates) and high-salt foods; (2) adopting an organic, low-iron (absent anemia), plant-based, high fi ber diet focused on high-sulfur foods (garlic, onions, whey protein, and eggs) and cruciferous veg- etables (broccoli, Brussels sprouts, beet greens, cabbage); (3) consuming healthy fats (omega 3; monounsaturated); (4) drinking at least eight, 8-oz glasses of non-city/fi ltered/high pH water, up to one- half of one’s body weight in water daily; and (5) avoiding pro-infl ammatory foods such as dairy, gluten, excess alcohol, and processed meats.
Lifestyle considerations to support a
fatty liver include reducing exposure to food additives/colors, heavy metals, and pesticides and other airborne toxins, ex- ercising 20-30 minutes per day, and daily detoxing (organic lemon and water; green and other detox teas).
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Some Important Liver-Supportive Dietary Supplements
Given that no medication exists to
treat or cure liver disease adequately, and the liver’s enormous capacity to regener- ate, it makes sense to consider dietary supplements that are proven to promote ongoing liver health. Scientifi c studies support the use of the nutrients below,
among others, to increase the liver’s ca- pacity to function effectively and detoxify.
1. Amino Acids: Aging decreases
the sulfur-containing, liver detoxifying amino acids L-cysteine and L-methionine. Their levels greatly dictate how much the body produces free radical-fi ghting cel- lular glutathione, considered the “master antioxidant.” Research has established that N-acetyl cysteine (NAC) supple- mentation reduces heavy metal and drug toxicity and can improve liver function in NAFLD patients. L-carnitine is an es- sential nutrient that converts fat to energy in the liver’s powerhouses, and thus is critical to their function. Defi ciencies can increase susceptibility to NAFLD, and studies have established that L-carnitine supplementation improves liver damage. SAM-e (S-adenosyl methionine), crucial to the methylation pathway in Phase II detoxifi cation, is made in the body from L-methionine and vitamin B12, folic acid, and choline. SAM-e defi ciency is associ- ated with impaired detoxifi cation and can exacerbate liver injury. Supplementation with SAMe at the correct dosage has been shown to support liver function, but may have only limited value in treating certain chronic liver diseases.
2. Dandelion: Various holistic practi-
tioners recommend the leaves and root ex- tract of this herb for liver, gallbladder, and bile duct conditions, due to its antioxi- dant, anti-infl ammatory, anti-carcinogenic, anti-lipidemic, and anti-fi brotic proper- ties. Dandelion’s use has been shown to lower AST and ALT, marker enzymes of liver toxicity. Those allergic to ragweed, chrysanthemums, marigolds, and daisies, should avoid consuming it.
3. Green Tea Extract (GTE): This nutrient is widely viewed as benefi cial in the prevention and treatment of NAFLD. In one 2016 randomized, double-blind, placebo controlled, 90-day study of 80 NAFLD patients, researchers concluded that 500mg/day of GTE lowered AST and ALT liver enzymes, such that GTE can generally be considered a valid treatment to improve serum levels of liver enzymes in NAFLD patients.
4. Milk Thistle/Silymarin. As milk thistles’ main fl avonoid antioxidant, silymarin (with silybin, one of its three active components) protects the liver both by preventing depletion of its glutathione levels, and enhancing its detoxifi cation capacity by reducing the oxidative stress resulting from toxin metabolism. For over two decades, Michael Dworkin, PD, CCN,
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