Benefit from mistletoe therapy has been seen in the following types of cancer: breast, lung, colon, pancreatic,


stomach, ovarian, cervical, melanoma, and others..


tumor growth. In addition, mistletoe lectins protect the DNA of healthy cells.


Multiple human trials have been conducted to assess the effectiveness of mistletoe therapy in integrative cancer treat- ment. Benefits seen in clinical trials include reduction of chemotherapy-induced side effects: fatigue, nausea, vomiting, decreased appetite, liver toxicity, and immune sup- pression. Improved quality of life, improved pain, and trends toward improved survival have been demonstrated in human trials as well. Through improving treatment side effects, the incorporation of mistletoe may also improve compliance and completion of conventional treatment, improving over- all response to treatment.


A 2004 retrospective study of 1442


women with breast cancer compared women receiving conventional treatment alone with women receiving conven- tional treatment and mistletoe therapy. The women who received the additional mistletoe experienced fewer side effects from the chemotherapy. A systematic review of 26 randomized controlled trials found an improved quality of life in 22 of the 26 trials. Chemotherapy side effects were reduced as well.


Benefit from mistletoe therapy has been seen in the following types of cancer: breast, lung, colon, pancreatic, stomach, ovarian, cervical, melanoma, and others. Most of the research supports use in the setting of solid tumors (ex: breast, prostate, lung, ovarian), though there is data support- ing the use in blood cancers (leukemia) as well, particularly for reducing side effects.


Mistletoe is the most widely used complementary cancer therapy in Europe and is approved for palliative care in many European countries. However, mistletoe remains outside of the mainstream cancer treatment paradigm in the U.S. With con- tinued research in the U.S., hopefully the status will shift.


Johns Hopkins Kimmel comprehen-


sive cancer center is currently enrolling a Phase I clinical trial to assess the safety of


intravenous mistletoe therapy. You may visit clinicaltrials.gov and enter trial identifier: NCT03051477 for more information.


Cancer Management and Treatment Integrative and holistic cancer treat-


ment incorporates a five-pronged approach to cancer management and treatment, including the following:


• Conventional Treatment (chemotherapy/radiation/ targeted therapy)


• Nutraceuticals/Natural Supplements • Dietary Recommendations • Lifestyle Counseling • Mental/Emotional/Spiritual health Mistletoe therapy falls under both the


nutraceutical and mental/emotional/spiri- tual groups. The use of mistletoe causes biochemical and immune responses within the body, evidenced by skin reactions and lab results. In addition, based on anthro- posophical medicine philosophy, mistletoe induces an energetic healing effect on the body and cancer process.


Although occasionally used as a stand- alone treatment, Mistletoe therapy provides the greatest benefit when used within an integrative setting, alongside conven- tional treatment. Using mistletoe after the completion of conventional treatment may reduce the risk of disease recurrence. In addition, mistletoe therapy offers benefit in precancerous conditions including atypical ductal hyperplasia and cervical dysplasia. Although more nuanced, there may also be a role of mistletoe therapy in some auto- immune conditions.


Safety The FDA (Federal


Drug Administration) categorizes mistletoe therapy as a generally recognized as safe (GRAS) homeopathic preparation. A recent study found that mistletoe therapy did not interact with drug metabolism enzymes and concluded that concurrent use of mistletoe with medi- cations is likely safe (BMC Complemen- tary and Alternative Medicine volume 17, Article number: 521, 2017). The trials com- bining mistletoe with conventional treat- ment found trends towards prolonged


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