IN THIS ISSUE


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8 LIPIDS Improving the Performance of Lipid Formulations: Nanoparticle Layers and Solid Hybrid Particles


Angel Tan, Ph.D. and Clive Prestidge, Ph.D. Ian Wark Research Institute, University of South Australia


30 DISSOLUTION Analysis of the Biorelevance of the Main Methods used to Compare In Vitro Dissolution Profi les


María Esperanza Ruiz, Ph.D. National University of La Plata (UNLP) Argentinean National Council for Scientifi c and Technical Research (CONICET)


34 RMM Rapid Microbiology and the Newly Revised PDA Technical Report No. 33


Michael J. Miller, Ph.D. Microbiology Consultants, LLC


SPECIAL FEATURES


28 Capsugel Advertorial 45 Fresh Perspectives 2013 47


Implementing a Single-Use Biomanufacturing Strategy: Important Considerations


50 Millifl ex® Quantum – Detection of Microbial Contaminants in Water Samples


54 Optimization of Primary Drying Time Using a Combination of ControLyo™ Nucleation on Demand and SMART™ Freeze Dryer Technology


58 Leveraging the Benefi ts of Raman Spectroscopy


61 Enhanced Classifi cation of Placebo and Active Formulations via Hierarchical Modeling


68 LyopAt™: Real-Time Monitoring and Control of the Freezing and Primary Drying Stages During Freeze-Drying for Improved Product Quality and Reduced Cycle Times


REGULAR FEATURES 7


75 80


Editorial Advisory Board IFPAC 2014 Preview Industry News


86 Online Features 87 Classifi ed Advertisements 88 Advertiser’s Index


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| November/December 2013


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