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ROUNDTABLE
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Spectroscopic Techniques and PAT: Roundtable
Gary Ritchie President Council for Near Infrared Spectroscopy (CNIRS)
Mark Sullivan, Ph.D. Senior R&D Scientist Advantest America, Inc.
How does the movement from lab-based instruments to portable tools in the industry bolster PAT?
GR:
More broadly, it allows measurements to be made in locations where standard lab instruments are not easily implemented,
for example on loading docks, and in the fi eld. “Portable” covers a wide range, from handheld to truck-mounted. An appropriate unit should be selected, depending on the expected conditions to be encountered, including the precision and accuracy needed. Specifi cally, one of the objectives of PAT is to reduce the cycle times for batch manufacturing and release. Performing laboratory tests and waiting for the results consumes a large amount of time. Removing the in-process sampling step and being able to make measurements at the point of material processing will preserve time, and more importantly reduce the “run at risk” mode that many manufacturers practice currently.
BM:
Brian Marquardt, Ph.D. Director Center for Process Analytical Chemistry University of Washington
Claudia Corredor Research Investigator II Bristol-Myers Squibb
Robert Chimenti Sr. Strategic Applications Engineer Innovative Photonic Solutions
The size and cost reduction of traditional lab instrumentation into portable tools drives the expanded
use of the technology to improve process control and product quality. The caveat with this argument is when smaller, faster and cheaper leads to inaccurate results or poor data. This is where I have seen the move to portable tools being a detriment to companies and PAT overall. All it takes is one person selling a bad solution into a company for all process measurements to get a bad name in that company. There are, however, many examples where small, portable Raman, NIR and IR handhelds have been eff ectively applied to improve quality. Using handheld Raman to screen raw material for use in a pharmaceutical process is an example.
Identify noteworthy advances in NIR instrumentation. What are the key drivers for these advancements?
“Faster, smaller, cheaper” is here! 1000 spectra per microseconds, 50 mm diameter or less sampling windows and under $1,000 is now a reality. The development of Diode-Array (DA),
GR: 22 | | November/December 2013
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