»


CHROMATOGRAPHY


»


Senior Scientific Manager of the Small Molecule Analytical Chemistry and Quality Control Group at Genentech.


Nik Chetwyn Ph.D., is the Head of the Small Molecule Analytical Chemistry and Quality Control group at Genentech. Prior to joining Genentech, he was an Associate Director at Pfizer and a Research Investigator at GlaxoSmithKline. Nik received his Ph.D. from the University of Kansas.


References 1.


2. 3. 4. 5. 6. 7. 8. 9. 10.


17. Groskreutz SR, Swenson MM, Secor LB, Stoll DR. Selective comprehensive multi-dimensional separation for resolution enhancement in high performance liquid chromatography. Part I: Principles and instrumentation. Journal of Chromatography A 2012, 1228 (0), 31-40.


18.


Schiesel S, Lämmerhofer M, Lindner W. Comprehensive impurity profiling of nutritional infusion solutions by multidimensional off-line reversed-phase liquid chromatography×hydrophilic interaction chromatography-ion trap mass-spectrometry and charged aerosol detection with universal calibration. Journal of Chromatography A 2012, 1259, 100-110.


19.


Huidobro AL, Pruim P, Schoenmakers P, Barbas C. Ultra rapid liquid chromatography as second dimension in a comprehensive two-dimensional method for the screening of pharmaceutical samples in stability and stress studies. Journal of Chromatography A 2008, 1190 (1-2), 182-190.


Erni F, Frei RW. Two-dimensional column liquid chromatographic technique for resolution of complex mixtures. Journal of Chromatography A 1978, 149 (0), 561-569.


Guiochon G, Beaver LA, Gonnord MF, Siouffi AM, Zakaria M. Theoretical investigation of the potentialities of the use of a multidimensional column in chromatography. Journal of Chromatography A 1983, 255 (C), 415-437.


Giddings JC. Two-dimensional separations: concept and promise. Analytical Chemistry 1984, 56 (12), 1258A-1270A.


Liu Z, Patterson DG, Lee ML. Geometric Approach to Factor Analysis for the Estimation of Orthogonality and Practical Peak Capacity in Comprehensive Two-Dimensional Separations. Analytical Chemistry 1995, 67 (21), 3840-3845.


International Conference on Harmonization (ICH) Guidelines. Impurities in new drug substances Q3A (R2). October 2006.


Internatinoal Conference on Harmonization (ICH) Guidelines. Impurities in new drug products Q3B (R2). June 2006.


Sheldon EM. Development of a LC–LC–MS complete heart-cut approach for the characterization of pharmaceutical compounds using standard instrumentation. Journal of Pharmaceutical and Biomedical Analysis 2003, 31 (6), 1153-1166.


Schadt HS, Gössl R, Seibel N, Aebischer CP. Quantification of vitamin D 3 in feed, food, and pharmaceuticals using high-performance liquid chromatography/tandem mass spectrometry. Journal of AOAC International 2012, 95 (5), 1487-1494.


Zhang K, Li Y, Tsang M, Chetwyn NP. Analysis of pharmaceutical impurities using multi- heartcutting 2D LC coupled with UV-charged aerosol MS detection. Journal of Separation Science 2013, 36 (18), 2986-2992.


Lee C, Zang J, Cuff J, McGachy N, Natishan TK, Welch CJ, Helmy R, Bernardoni F. Application of Heart-Cutting 2D-LC for the Determination of Peak Purity for a Chiral Pharmaceutical Compound by HPLC. Chromatographia 2013, 76 (1-2), 5-11.


11. Matejicek D. Multi heart-cutting two-dimensional liquid chromatography–atmospheric pressure photoionization-tandem mass spectrometry method for the determination of endocrine disrupting compounds in water. Journal of Chromatography A 2012, 1231 (0), 52-58.


12. 13.


Stoll DR. Recent progress in online, comprehensive two-dimensional high-performance liquid chromatography for non-proteomic applications. Analytical and Bioanalytical Chemistry 2010, 397 (3), 979-986.


Venkatramani CJ, Zelechonok Y. An automated orthogonal two-dimensional liquid chromatograph. Analytical Chemistry 2003, 75 (14), 3484-3494.


14. D’Attoma A, Grivel C, Heinisch S. On-line comprehensive two-dimensional separations of charged compounds using reversed-phase high performance liquid chromatography and hydrophilic interaction chromatography. Part I: Orthogonality and practical peak capacity considerations. Journal of Chromatography A 2012, 1262, 148-159.


15.


Alexander AJ, Ma L. Comprehensive two-dimensional liquid chromatography separations of pharmaceutical samples using dual Fused-Core columns in the 2nd dimension. Journal of Chromatography A 2009, 1216 (9), 1338-1345.


16. Groskreutz SR, Swenson MM, Secor LB, Stoll DR. Selective comprehensive multidimensional separation for resolution enhancement in high performance liquid chromatography. Part II: Applications. Journal of Chromatography A 2012, 1228 (0), 41-50.


44 | | November/December 2013 31. 32. 33. 22. 23. 24.


20. Ni Y, Liu Y, Kokot S. Two-dimensional fingerprinting approach for comparison of complex substances analysed by HPLC-UV and fluorescence detection. Analyst 2011, 136 (3), 550-559.


21.


Reichenbach SE, Kottapalli V, Ni M, Visvanathan A. Computer language for identifying chemicals with comprehensive two-dimensional gas chromatography and mass spectrometry. Journal of Chromatography A 2005, 1071 (1–2), 263-269.


Reichenbach SE. Quantification in Comprehensive Two-Dimensional Liquid Chromatography. Analytical Chemistry 2009, 81 (12), 5099-5101.


Mondello L, Herrero M, Kumm T, Dugo P, Cortes H, Dugo G. Quantification in Comprehensive Two-Dimensional Liquid Chromatography. Analytical Chemistry 2008, 80 (14), 5418-5424.


Conti M, Motta R, Puggioli C, Brambilla P. Surface-activated chemical ionization-electrospray ionization mass spectrometry combined with two-dimensional serial chromatography is a powerful tool for drug stability studies. Rapid Communications in Mass Spectrometry 2013, 27 (11), 1231-1236.


25. Donato P, Cacciola F, Tranchida PQ, Dugo P, Mondello L. Mass spectrometry detection in comprehensive liquid chromatography: Basic concepts, instrumental aspects, applications and trends. Mass Spectrometry Reviews 2012, 31 (5), 523-559.


26. 27.


Pastor-Navarro MD, Porras-Serrano R, Herráez-Hernández R, Campíns-Falcó P. Automated determination of amphetamine enantiomers using a two-dimensional column-switching chromatographic system for derivatization and separation. Analyst 1998, 123 (2), 319-324.


Barreiro JC, Vanzolini KL, Cass QB. Direct injection of native aqueous matrices by achiral-chiral chromatography ion trap mass spectrometry for simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions. Journal of Chromatography A 2011, 1218 (20), 2865-2870.


28.


Liu Q, Jiang X, Zheng H, Su W, Chen X, Yang H. On-line two-dimensional LC: A rapid and efficient method for the determination of enantiomeric excess in reaction mixtures. J Sep Sci 2013, http://dx.doi.org/10.1002/jssc.201300412.


29. Hamase K, Morikawa A, Ohgusu T, Lindner W, Zaitsu K. Comprehensive analysis of branched aliphatic d-amino acids in mammals using an integrated multi-loop two-dimensional column- switching high-performance liquid chromatographic system combining reversed-phase and enantioselective columns. Journal of Chromatography A 2007, 1143 (1–2), 105-111.


30.


Venkatramani CJ, Wigman L, Mistry K, Chetwyn N. Simultaneous, sequential quantitative achiral–chiral analysis by two-dimensional liquid chromatography. Journal of Separation Science 2012, 35 (14), 1748-1754.


Jayamanne M, Granelli I, Tjernberg A, Edlund PO. Development of a two-dimensional liquid chromatography system for isolation of drug metabolites. Journal of Pharmaceutical and Biomedical Analysis 2010, 51 (3), 649-657.


Rezadoost H, Ghassempour A. Two-dimensional hydrophilic interaction/reversed-phase liquid chromatography for the preparative separation of polar and non-polar taxanes. Phytochemical Analysis 2012, 23 (2), 164-170.


Yamamoto E, Niijima J, Asakawa N. Selective determination of potential impurities in an active pharmaceutical ingredient using HPLC-SPE-HPLC. Journal of Pharmaceutical and Biomedical Analysis 2013, 84, 41-47.


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92