» LIPIDS


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the effect of dietary fats (Figure 5). The fact that the hybrid formulation contained less than 1g lipid dose in comparison with 35g of fat content present in the food clearly highlights the important role of the nanostructured carrier network in maximizing the “food-mimicking effect”, which has potential implication for removing the fed-fasted variations in drug absorption.


Conclusion


Lipid-based dosage forms represent an important class of solubilized formulations for low solubility drugs when other physical modification approaches (e.g. micronization and crystal habit modification) produce only modest improvements in their gastrointestinal dissolution and absorption. The coupling of lipid colloids with silica nanoparticle adlayers and specific nanostructures potentially improves the performance of lipid formulations in terms of drug loading efficiency, control of enzymatic digestion kinetics, and drug release behavior in comparison with lipids in their bulk or original states. Importantly, such nanostructured hybrid formulations have demonstrated attractive potential in maximizing oral drug bioavailability while mitigating pharmaceutical food effects, hence offering new options in the formulation and delivery of challenging molecules.


Author Biographies


Dr. Clive Prestidge is the Professor of Colloid and Pharmaceutical Science at the University of South Australia and the Associate Director for Nanomedicine at the Ian Wark Research Institute. Clive’s research group focuses on nanomaterials for biological application. He has contributed over 120 journal articles and is the inventor of a number of patent families for drug encapsulation and delivery.


Dr. Angel Tan is a post-doctoral Research Associate in nanomedicine research at the Ian Wark Research Institute, University of South Australia. Her primary research interests are in the design and mechanistic investigation of functional hybrid nanomaterials for the oral delivery of poorly water-soluble therapeutics, with a focus on their translation into clinical applications.


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