ANALYTICAL AND LABORATORY EQUIPMENT 7
Flexibility and speedy data analysis key for omics technologies
Large scale proteomics and metabolomics projects rely on high- speed data analysis software, together with fast throughput analysis systems. Sean Ottewell reports on the latest developments.
Les projets protéomiques et métabolomiques à grande échelle reposent sur des logiciels d’analyse des données à grande vitesse couplés à des systèmes d’analyse à débit rapide. Sean Ottewell rend compte des derniers développements.
Große Projekte in den Bereichen Proteomik und Metabolomik greifen auf Software für die schnelle Datenanalyse sowie leistungsstarke Analysesysteme zurück. Sean Ottewell berichtet über die neuesten Entwicklungen.
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B SCIEX has launched its new Eksigent ekspert nanoLC 400 system, the
world’s first plug-and-play liquid chromatography (LC) system that integrates nano LC and micro LC on the same platform. As such it provides the broadest functionality with the benefits of both flow rate ranges. Tis flexibility enables fast and easy switching between high- sensitivity discovery proteomics and the high-throughput targeted peptide quantitation commonly used in advanced biological studies.
Discovery proteomics is a strategy in which an LC system in combination with a mass spectrometer is used to identify and quantify proteins in a global untargeted manner. Once a set of interesting proteins has been identified, targeted techniques are
used to verify and validate the results in further sample types by targeted peptide quantitation. Te ultimate goal is to advance the understanding of systems biology by identifying new biomarkers or new proteins of interest and to potentially improve medical methodologies.
Te new Eksigent ekspert nanoLC 400 system improves the efficiency of these proteomics workflows by providing the highest separation quality and reliability.
Te novel, interchangeable LC flow modules in the nanoLC 400 system allow scientists to quickly go from low flow nano LC to a higher flow rate of micro LC, with a simple switch of a module. Tis is ideal for mixing non-targeted and targeted approaches, especially
when used with a next-generation mass spectrometer such as the AB SCIEX TripleTOF 5600+ system. In addition, the retention time stability afforded by advances in microfluidic flow control (MFCPlus technology) is critical for quantitative applications such as Scheduled MRMHR Workflow and SWATH Acquisition.
“Scientists want to do more with less,” said Remco van Soest, product manager for the ekspert nanoLC 400 system at AB SCIEX. “Because the new ekspert nanoLC 400 system bridges the gap between low flow and higher flow rates in LC/MS workflows, laboratories no longer need separate LC systems to go from discovery to verification and validation in the protein biomarker research continuum. Te plug-and- play functionality of the nanoLC
Right The new version of Qlucore’s visualisation software simplifies data exchange and lets researchers be more creative when presenting their findings.
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