50 BIOTECHNOLOGY


Ready-to-use RNA range expanded


AMSBIO has expanded its range of ready-to-use RNA samples to now include mRNA/microRNA tissue preparations and a large number of RNAs from mouse and rat development stages. AMSBIO has generated over 4,000 individual total


RNAs ready to go off-the-shelf, many with bioanalyser RIN scores to demonstrate their high quality. Isolated from a variety of tissues - the AMSBIO biorepository of RNA samples covers over 30 species including human, animal, plant, insect and cell line. Included within the biorepository are a wide range of normal tissue types as well as tissues of human disease conditions, from multiple donors, that are typically difficult to source. AMSBIO’s range of total RNA isolated from major


organs (embryonic stages to adult) includes RNA from individual brain regions that are difficult to obtain because of their size and anatomical complexity. Also available are a comprehensive collection of preparations from placenta, uterus and embryo tissues at different stages of pregnancy plus a complete library of mammary gland specimens from non-pregnant, pregnant, lactating, and involuted animals. AMSBIO offers customers panels of convenient,


ready-to-use RNAs. Stringent quality control tests are performed on all AMSBIO tissue preparations to confirm the integrity and stability of their RNA. These purified RNAs are invaluable ready-for-use tools, provided in convenient sizes, for various downstream applications, including microarray hybridization, PCR cDNA synthesis


and RT-PCR analysis. Meanwhile, a unique


Extracellular Matrix (ECM) Mimetic Library for engineering surfaces to direct receptor binding specificity, signalling and growing cells in 3D has been launched by AMSBIO. Containing nearly 300 biomimetics of Fibronectin, Vitronectin, Laminin and Collagen, for coating plates or creating 3D culture scaffolds, AMSBIO’s new ECM combinatorial library provides a powerful tool for identifying the cellular adhesion profile of your cell line or tumour against the widest commercially available collection of cell surface receptor binding peptide motifs. The extracellular microenvironment, defined by


biochemical and physical cues, is a deciding factor in a wide range of cellular processes not confined solely to oncology. These include cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions. Being able to engineer the ECM microenvironment


provides clear benefits in studies of cell and tissue engineering and related applications. Currently existing technology offers simple (and merely adequate)


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Adam Equipment Affymetrix BÜCHI Buck Scientific Bürkert Catalent Gilson Guerin Systems Keyence MSP Kofel


www.scientistlive.com


11 33


11A 28 12 52


12A 47 24 27


Molnar-Institute Ocean Optics Olympus SigmaPlot TCS Biosciences Thermo Scientific Vacuubrand Walter Rau Zeiss Zinsser Analytical


39A 37


33A 28A 6


31 39 45 15 9


environments that facilitate basic cell processes such as adhesion. The simple presentation of motifs involved in cell adhesion is not optimal for controlling more integrated processes. Crosstalk among signalling pathways acts synergistically to enhance cellular responses such as cell adhesion and/or proliferation. A recent study showed that


a combination of extracellular matrix derived peptides presented on a surface may


enhance cell adhesion strength and focal adhesion assembly. This combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells. Based upon the AMSBIO ECM combinatorial


library, the ready to-use MAPTrix Array provides a means to regulate a variety of cell surface receptors for your cell studies. The basic layout of the MAPTrix Array is comprised of avß3 and its complementary integrins such as a2ß1 (collagen), a3ß1 (laminin), a5ß1 (fibronectin), and heparin binding motif.


For more information, visit www.amsbio.com


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