chromatography • spectroscopy 29
Achieving lower detection limits of volatile nitrosamines in tobacco
Eric Phillips and Mary Dennis discuss the use of triple quadrupole GC-MS/MS as a potential solution for accurate detection, measurement and analysis of VNAs in tobacco.
Eric Phillips et Mary Dennis examinent l’utilisation du triple quadripôle GC-MS/MS comme moyen potentiel de la détection, la quantification et l’analyse précises des nitrosamines volatiles spécifiques au tabac.
Eric Phillips und Mary Dennis diskutieren die Verwendung von Tripel-Quadrupol-GC-MS/MS als potentielle Lösung für die genaue Erkennung, Messung und Analyse von flüchtigen Nitrosaminen in Tabak.
V
olatile nitrosamines (VNAs) are a class of compounds that comprise
one of the most important groups of carcinogens found in tobacco-related products. Tese chemicals pose significant health risks to humans and, as such, it is fundamental to measure the amount of VNAs present in tobacco. Although gas chromatography (GC) and thermal energy analyser (TEA) detection have traditionally been successful
in the measurement of VNAs, these methods, used both separately and in conjunction with one another, face significant challenges in light of tightened regulations.
VNAs are formed during the processing of tobacco, as well as during the smoking of tobacco products by reaction of nitrogen oxide (NOX
) with amines. Tese
harmful compounds are present in both smokeless tobacco products and in cigarette smoke.
In 2008, the World Health Organization (WHO) published a technical report entitled ‘Te Scientific Basis of Tobacco Product Regulation’. Based on this report, a WHO study group recommended the mandated lowering of toxicants in cigarette smoke, including tobacco-specific nitrosamines and other selected constituents. Te report recommends a strategy for regulation based on product performance measures, with the goal of reducing toxicant levels in
Figs. 1-6. The matrix calibration curves ranged from 2-50ng/mL and 1-25µg/kg were extracted from matrix.
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