healthbriefs
over-production of histamine, leading to chronic rashes and hives. If this SNP is identifi ed, for example, eating foods with less histamine and taking a DAO supplement can make a signifi cant impact on lessening these bothersome symptoms.
Modern testing, such as the popular
NutriGenomics: Connecting Your Genetics
With Your Nutrition by Thomas Moraczewski, MD
ven though the genetic code was deciphered over ten years ago, its application to one’s personal health is still evolving. Various companies have been marketing individual testing of DNA, but the raw data on our 25,000 genes (the “genome”) remains confusing to interpret. Lately the variations in many of the genes, called SNPs (single nucleotide polymorphisms), have been connected with many health conditions such as cancer, detoxifi cation ability, heart disease and prenatal health. Thus, knowing our unique DNA—the “barcode” of life—will continue to make understanding our genomics an essential part of everyone’s health. SNPs are variations or mini- mutations in genes that may lead to enzyme and metabolism alterations. Most SNPs are harmless; others may have a profound impact on health. Much of the emerging research has focused the BRCA genes for breast cancer and the ApoE gene SNPs for cognitive impairment. But the most exciting area is understanding the way
E
we absorb and process nutrition, called “nutrigenomics.” By studying one’s unique genome, the need for certain vitamins, enzymes, supplements and minerals will lead to improved health. One example is the MTHFR gene
SNP variations (A1298C and C677T) that relate to methylation. Methylation is a biochemical process within each cell of our bodies. These genes code for enzymes that repair DNA, metabolize hormones such as estrogen, work to make neurotransmitters (such as serotonin, dopamine, B12 and folate utilization) and detoxify environmental toxins. SNP mutations may be involved with recurrent miscarriages and birth defects such as spina bifi da. Other SNPs once identifi ed may lead to anxiety and depression (by altering neurotransmitter production), faulty detoxifi cation of heavy metals, cigarette smoke, exhaust fumes. Other problems include GI health and possible leaky gut syndrome, faulty iron utilization, poor Vitamin D absorption, Glucose issues, cholesterol problems, and gluten intolerance. SNPs may, also, cause an
saliva 23 and Me test, will tabulate several dozen of the SNPs. One cannot simply “treat” the genetic variation with vitamins, supplements and minerals without assessing if that gene variation is actually causing a metabolic problem. If a MTHFR mutation is detected, for example, 2/3 of the patients will need methylated forms of folate and B12— but 1/3 will actually over-methylate and supplementation will lead to a worsening of problems such as anxiety, panic attacks and depression. Hence, other genetic “roadblocks” must also be analyzed along with further testing for the gene functioning. To make proper sense of these DNA results, additional tests usually will include urinary organic acids, salivary hormones, plasma homocysteine levels and urine neurotransmitters. It is a complex puzzle that must be deciphered to improve one’s health. Fortunately, nutrigenomic computer
programs such as those developed by Naturopathic Physician Dr. Bob Miller will allow the DNA data along with other test results to make a proper nutritional and targeted supplement plan customized to each person. Physicians trained in interpretation of the DNA and testing data will be able to help patients understand their unique DNA blueprint and improve their health immensely.
Thomas Moraczewski, MD is board-certifi ed in Obstetrics-Gynecology and Anti-Aging and Regenerative Medicine for both men and women. Dr. Moraczewski is Fellowship
trained in both Anti-Aging & Functional Medicine as well as Advanced Metabolic Endocrinology. He brings his 30+ years of experience to the practice with a focus on women’s wellness, anti-aging, nutritional and hormonal medicine. He is now offering testing and consultation for NutriGenomics. Call the Center for Natural and Integrative Medicine for more information at 407-355-9246 x 308.
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