PROMOTION HYALURONIC ACID FILLERS NEAUVIA ORGANIC
MATEXLAB unveil their new technology to obtain real improvements in hyaluronic acid filler performance
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Nicola Zerbinati, MD, PHD, Teacher of Aesthetic Medicine in the Postgraduate Course in Aesthetic Medicine at the University of Pavia, directed by Professor G. Robutti. Dr Zerbinati works as a dermatologist in his private practices (CMP), and since November 2000 teaches Dermatology and Venereology at the University of Insubria, Varese (Italy). He is also Scientific Coordinator of the International Academy of Cosmetic Gynaecology (IACG).
YALURONIC ACID
(HA) dermal fillers are used in a great number of procedures each year due to their unequaled
ease of administration, effectiveness, and safety profile. According to recent statistics, the majority of aesthetic procedures carried out in the US currently occur with HA dermal fillers. This trend is expected to increase since there is presently no other class of filling agent that rivals the properties and advantages of HA fillers. A new era for HA based fillers has
arrived. MATEXLAB, a Swiss company employing people with 20 years of experience in manufacturing fillers and biomaterial, introduced Neauvia Organic to the market, a line of products derived from the fermentation of the safe, probiotic and non-pathogenic bacterial strain Bacillus Subtilis and from the PEG polymer as cross-linker.
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Innovative raw material The innovative raw material is based on a HA extract from Bacillus Subtilis, instead of that extracted from Streptococcus Equi. The difference is perceptible and substantial in terms of safety and biocompatibility. This new kind of hyaluronian is a patented HA extraction in distilled water, so without the need of any chemical solvent. The ultrapure raw material does not contain any protein, nucleic acid, or endotoxins, which are the main contaminants responsible for allergic reactions, because the bacteria membrane is
October 2015 |
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not broken to extract the HA as it is during the Streptococcus Equi process.
Crosslinking with PEG polymer The scientist at MATEXLAB substituted the current monomer used as a cross-linker (BDDE), with a safer and more mechanical resistant polymer (PEG). Increased safety is due to the lower level of toxicity of PEG in comparison with BDDE (lethal dose is 30 times lower) and due to the ability of PEG in stopping the immunological reaction, blocking the formation of the FBGC. Mechanical resistance is due to the real interpenetrating polymer network (IPN)
technology where both the
polymers get advantages from the combination with the other and from the unique property of PEG to delay the degradation by proteolytic enzymes. The advantages are strongly evident both in terms of safety and in terms of mechanical
properties. So, no more choosing between safety and long-lasting effect.
Double action filler Neauvia Organic Stimulate is the first product worldwide with double action: filler effect, thanks to the cross- linked HA; and bio-stimulation effect due to a very safe use of CaHA (just 1%). The use of PEG as a crosslinking agent allows the allocation, during the manufacturing process, of 8 to 12 micron size molecules of CaHA inside the clusters of the polymer. During the natural degradation of the product, there is a continuous release of small particles of CaHA, which is a naturally occurring mineral, safe for the human body, stimulating the process of neocollagenesis and the density and the structure of the skin. The application of hydroxyapatite contained in Neauvia fillers is not interfering with the perfect volumetric and revitalizing effect of hyaluronic acid.
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