PEER-REVIEW | MICRONEEDLING |


A NEW MICRONEEDLING TREATMENT FOR


CROW’S FEET LINES


Benji Dhillon discusses the results of an 8 week study on the effects of microneedling with Radara® on crow’s feet lines


ABSTRACT Microneedling as an anti-ageing modality has been subject to increased interest due to its ability to help improve the appearance of fine lines and wrinkles. However current devices are faced with a


ageing treatments. Advances in the understanding of how skin ages has, however, led to the development of alternative treatment modalities such as chemical peels, various laser devices, radiofrequency, and injectional lipolysis, all of which can either act independently or as effective adjuncts to traditional injectables. Microneedling (MN), otherwise known as collagen induction therapy, has been subject to increased interest in its ability to rejuvenate the skin by targeting the deep layers of the epidermis. The injury induced by the procedure can initiate the release of growth factors stimulating neo-collagenesis and elastin, as well as promote neo-vascularisation, which has been demonstrated to improve the appearance of scars2,3,4


I 42  .


Additionally, by piercing the stratum corneum, multiple channels can be created in the epidermis, facilitating the transport of molecules to help improve the skin’s appearance5


. The benefits of MN include its non-invasive nature,


leading to minimal disruption of the epidermis, therefore limiting adverse effects and minimizing downtime6


.


However, most current MN devices can lead to some degree of bleeding, given the number and size of needles.


October 2015 | prime-journal.com


KEYWORDS Microneedling, Crow’s feet, wrinkles, Radara®


number of limitations such as pain, erythema and bleeding. A split face observational study was conducted involving thirty-two


patients who


were followed up for 8 weeks after using a novel microneedling product, Radara® and hyaluronic acid serum


N RECENT YEARS THERE HAS BEEN A STEADY increase in the number of options to help combat the signs of ageing1


. Traditional injectable


treatments such as botulinum toxin and dermal fillers, the latter of which continue to be subject to rapid innovation, are the mainstay of current anti-


on the crows feet line area and serum alone on the contralateral side. 3D imaging results at 4 weeks demonstrated a 35% improvement in wrinkles from baseline within the Radara® group versus 24% for the serum only group. Additionally no


unwanted skin reactions or pain were reported. The results are encouraging for Radara® as an innovative pain free microneedling modality to temporarily improve crow’s feet lines between traditional botulinum toxin treatments


Additional limitations include variability in the volume of molecules that passively pass through the skin, as well as limited MN sizes. Innoture Limited’s Research and Development team


BENJI DHILLON, MRCS, BSC, Phi Clinic. 102 Harley Street, London


email: benjeev@doctors.org.uk


working alongside the Institute of Life Sciences at Swansea University have developed and patented a proprietary manufacturing printing process that allows for the development of multiple MN’s (Figure 1) to create micro-channels (Figure 2) in the skin, allowing for the passage of various molecules. The manufacturing process is unique in that it allows for the production of various needle sizes and patterns onto flexible substrates over large surface areas, which conform easily to the skin’s surface (Figure 3). Although the technology has the potential for application in various aesthetic and therapeutic indications, its utility and efficacy is first being explored with the Radara® patch, in the correction of fine lines and wrinkles within the lateral canthal or crows feet lines (CFL) area. Each Radara® patch contains 2000 MN’s, all equally


spaced at approximately 700m (Figure 4) from tip to tip, and are approximately 200m in diameter tapering to 100m at the top. Early skin permeation studies in the development of the patch, revealed that MN’s must be above 350m and at approximately 500m to have an efficiency of penetration of up to 80%7


. Hence the Radara®


patch MN’s are 550m in length with a variability of +/- 50m.


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