| DERMATOLOGY | PEER-REVIEW
against extracellular microorganisms and the pathogenesis of different autoimmune diseases6,7 Scientific data confirms an active role of IL-17 in
.
the development of inflammatory diseases, autoimmune pathogenesis, and malignant tumors8
.
The signal pathway of IL-17 functions in different tissues, such as cartilage, bone, meniscus, brain, hemotopoietic tissue, lung, kidney, skin, and bowel. Hence, ligands and receptors for the IL-17 family may play a major role in tissue homeostasis and in the pathological processes of the immune system. Increased levels of IL-17 are associated with a number of pathological conditions, such as respiratory tract inflammation, rheumatoid arthritis, intraperitoneal abscesses, inflammatory bowel diseases, psoriasis, cancer, and multiple sclerosis8 The role of IL-17 in psoriasis and
.
atherosclerosis remains unclear and is the reason behind the authors’ decision to investigate the role of IL-17 in molecular mechanisms during the development of these diseases. With the aid of real-time polymerase chain reaction (PCR) the authors analysed and compared the gene expression levels for IL- 17 in visually unaffected skin and psoriatic lesions in psoriasis patients, as well as atherosclerotic affected vessels and unaffected parts of the femoral artery in atherosclerosis patients, respectively.
Materials and methods A total of 20 patients diagnosed with either psoriasis or atherosclerosis were recruited from the P.V. Mandryk State Medical Center and the dermatology department of the state hospital (Moscow, Russian Federation). The study was approved by the local ethics committee at the Genetics Institute of the Russian Academy of Sciences (RAS) and was conducted in agreement with the principles of the Declaration of Helsinki. Characteristics of patients enrolled in the study are
listed in Table 1. The first group includes 10 patients (5 men and 5 women) with psoriasis. The second group includes patients with atherosclerosis of large blood vessels who have undergone surgery for artery stenosis.
1,3V.V. SOBOLEV, 1,2
M.E.
SAUTIN, 2E.S. PIRUZIAN, 1I.M. KORSUNSKAYA,
4A.V.MELERZANOV 3
Center for Theoretical Problems of Physico-Chemical Pharmacology, Russian
PIRUZYAN, 1
Academy of Sciences, Moscow; 2
Vavilov’s Institute of General Genetics, Russian Academy of
Mechnikov’s Research Institute of Vaccines and Serums, RAMS,
Sciences, Moscow; 3
Moscow, Russia; 4
Moscow Institute of Physics and Technology
email:
m83071@gmail.com O.A. SVITICH, 1A.A. LAVROV, 1 A.L.
Scientific data confirms an active role of
IL-17 in the development of inflammatory diseases, autoimmune
pathogenesis, and malignant tumors.
KEYWORDS Psoriasis, atherosclerosis, gene expression, IL-17
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