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1 Contents Head Office ISSN: 1752-8070


International Labmate Ltd. Oak Court, Sandridge Park, Porters Wood, St Albans, Herts AL3 6PH, UK Tel: +44 (0)1727 855574 Fax: +44 (0)1727 841694 info@chromatographytoday.com www.chromatographytoday.com


Michael Pattison, Chairman International Labmate Ltd.


Trevor Hopkins, Editor Chromatography Today Tel: +44 (0)7921 021378 trevor@intlabmate.com


Sales and Marketing Chris Jarvis, John Hobbs-Morris International Labmate Sales Team Tel: +44 (0)1727 855574


Carol A. Hardy


North American Area Manager Tel: +44 (0)623 869 0184 Carol@intlabmate.com


Editorial Review Board Dr. Paul Ferguson


President of the Chromatographic Society Associate Principal Scientist,


Astra Zeneca, Macclesfield, United Kingdom Professor Tony Edge


Vice President of the Chromatographic Society R&D Manager


Agilent Technologies, United Kingdom Dr. John Lough


Chromatographic Society Committee Member Reader in Pharmaceutical Analysis University of Sunderland, United Kingdom


Dr. Jonathan Crowther Senior Research Fellow


Ortho Clinical Diagnostics, United States Dr. Frank P. DiSanzo


ExxonMobil Research & Engineering Analytical Science Laboratory, United States


Ray T. McClain


Associate Principal Scientist Merck & Co. , Inc., United States


Dr. Lucie Nováková Associate Professor


Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic


Dr. Matthew Przybyciel


Vice President and Technical Director ES Industries, United States


Professor Torgny Fornstedt Analytical Chemistry


Department of Engineering and Chemical Sciences Karlstad University, Sweden


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Published with the full support of the Chromatographic Society by International Labmate Ltd.


Printed in the UK by Headley Brothers Ltd 56 Separation Science / Spectroscopy Meetings Calender


40 Navigating the Vast Array of Sample Prep- aration Techniques for Biological Samples –


Whole Blood


26 Improving Quantification of Protein Therapeutics by Standardising the Sample


Preparation Approach to LC-MS/MS Analysis: High-sensitivity Bioanalysis of Infliximab, and Total Antibody Quantification of the Antibody- drug Conjugate Trastuzumab Emtansine


34 Review of Microsampling Techniques in Bioanalysis


22 Miniaturisation in GC Laboratories - the Holistic Picture


18 Mixing Water and Gas:


The Quantitative Measurement of Water by Gas Chromatography Using Ionic Liquid Capillary Columns


14 Sample Preparation Options for Aroma Analysis


Over Years


2 Foreword by Dr Paul Ferguson Articles


4


The Benefits of Thermal Desorption Coupled with Gas Chromatography for the Analysis of Hydrocarbon Residues in Liquefied Petroleum Gas


10 Adding more Power to your GC-MS Analysis through Deconvolution


48 Using Micro-Elution SPE to Accelerate Sample Preparation for the Determination of Cannabis


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