search.noResults

search.searching

note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
52 August / September 2016 New Chiral Column Offered


Millipore Sigma, through its collaboration with ES Industries, offers a number of innovative and unique selective chiral stationary phases designed to solve chiral applications. Chirality has become critically important in the pharmaceutical, chemical and agricultural industries. Due to subtle differences, compounds that exhibit chiral activity can produce dramatically different pharmacological effects in biological systems. As a result, the demand for stereo selective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds has increased. Chiral chromatography in the forms of HPLC and SFC has become a necessary tool; not only for the analytical determination of enantiomeric purity, but also for the isolation and purification of enantiomers.


As a leader in chiral separations, the ChromegaChiral products offer a broad range of Chiral Stationary Phases (CSP’s) for analytical and preparative chromatography needs. Existing CSP’s can separate a wide variety of chiral mixtures; however there are still enantiomeric mixtures that are difficult to separate limiting their characterisation. This provides the drive to develop new CSP’s with differing chiral selectivities, e.g. ChromegaChiral CCA-F4 a chiral phase with embedded Fluorine atoms.


The addition of a fluorine atom into a phenyl carbamate amylose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds (1). A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine (2). ChromegaChiral CCA-F4 can be used in SFC or HPLC.


Product features Include: excellent selectivity range; high pressure limit; wide range of applications; fast optimisation; superior resolution and efficiency; one column for bBoth SFC and HPLC use; easy scale-up from analytical to preparative columns.


Information on the ChromegaChiral Phases can be found at: www.sigmaaldrich.com


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60