Delphinol:Delphinol is the standardised aqueous extract of berries from the Maqui bush (Aristotelia Chilensis), a shrub native to the Patagonian region of Chile. Maqui berries are a rich source of delphinidins, a specific type of flavonoid anthocyanin. Delphinol is standardised to contain a minimum of 35% total anthocyanins and 25% delphinidins respectively.
In a clinical study, Hidalgo et al (2014) reported the effect of delphinol supplementation on blood glucose levels in a double blind, placebo- controlled, cross-over trial using 10 healthy volunteers with moderate glucose intolerance.
The volunteers fasted for 12 hours, drank a beverage with 200 mg of Delphinol, or a matching placebo, and consumed 75 grams of boiled rice 30 minutes later. The placebo group showed a typical post-prandial sequence, commencing 30 minutes after rice consumption with blood glucose and insulin levels peaking after 60 minutes.
In contrast, the Delphinol group showed significantly lowered post prandial blood glucose and insulin levels compared to placebo. These data indicate that Delphinol supplementation may provide a useful strategy for maintaining healthy blood glucose levels in people with impaired glucose metabolism, particularly since SGLT activity is reportedly increased in Type II diabetes.
Chromium:The role of chromium in the management of blood glucose levels is relatively well established. Chromium is an essential component of chromodulin, a complex also comprising the amino acids glycine, cysteine, glutamic acid and aspartic acid.
Chromodulin in turn plays an important role in insulin signalling, effectively amplifying (up to 8-fold) the interaction of insulin with its cellular receptors, to facilitate glucose removal from the bloodstream.
The absorption of chromium from the digestive is very low, with supplemental chromium in chloride or picolinate forms typically having a bioavailability of 0.5 to 2%.
Adequate chromium intake may be particularly problematic in the elderly (Vaquero et al, 2002). ChromoPrecise ®, a type of chromium yeast with up to ten times the bioavailability of chloride or picolinate forms approved by the European Food standards Authority (EFSA), has been shown in clinical studies to significantly improve fasting plasma glucose and glycated haemoglobin levels in patients with type II diabetes (Racek et al, 2013).
For more information or to order Bio-Gluco Control capsules call Pharma Nord on 0800 591 756 or email
uksales@pharmanord.co.uk
Orders can be placed through your local UnitedDrug Sangers Sales Representative, your PMR system, or via the UnitedDrug Sangers telesales department on 028 9040 1531. n
References Hidalgo J et al (2014) Delphinol standardised maqui berry extract reduces postprandial blood glucose in individuals with impaired glucose regulation by novel mechanism of sodium glucose cotransporter inhibition. Panminerva Med; 56(3): 1-7.
Racek J et al (2013) Effect of chromium enriched yeast on fasting plasma glucose, glycated haemoglobin and serum lipid levels in patients with type 2 diabetes treated with insulin. Biol Trace Elem Res; 155(1): 1-4. 158-168.
Vaquero MP (2002) Magnesium and trace elements in the elderly: intake, status and recommendations. J Nutr Health Aging; 6(2): 147-153.
pharmacyinfocus.co.uk 15
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64