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Natural ingredients based on stem cell technology
Dr. Deok Hoon Park, President / CEO, BioSpectrum, Inc., discusses natural skin care ingredients based on stem cell technology
Along with the remarkable development of 21st century’s biotechnology, interest in new concept materials related to DNA, cell and biotelemetry systems are growing larger and larger. Cosmetics which adopted the concept of stem cells are emerging along with the wave of recent research on stem cells. Stem cell cosmetics can be defined as cosmetics with the stem cell technology being the major ingredient.
health, which is to maintain a dynamic balance by forming perfect harmony between skin composing cells or materials. Stem cells are the most important cell group in
terms of maintaining skin homeostasis which is the core of skin health. Cells formed to maintain skin homeostasis and restoration of a damaged part are all originated from stem cells. Implying, it is not too much to say skin health depends on
Three-colour cellular imaging on stem cells stained with ʻstemnessʼ marker
Different from other organs within our body, our skin is the organ covering the utmost part of our body which is always in contact with the external environment, and as such possesses various defence and restoration functions. Although our skin may always seem the same, in actual fact it is a very dynamic organ, with endless communications between the skin composing cells by enabling the process of old cells getting peeled off and new cells being formed, recovering from damaged parts due to external causes and blocking from external germs or invasion of other chemicals. It is very important to maintain homeostasis for skin
stem cells. Unfortunately, identical to other cells, the number of skin stem cells decrease and their functions decline with ageing, as they are also biological cells. Such decline of function leads to a fall in capability of defence and ultimately a lack of ability to suppress ageing, leaving wrinkles, age spots or other signs of skin ageing. Thus, if the stem cells are protected from ageing and if the functions of stem cells are maintained, these protected and activated stem cells will provide a big help in recovering overall skin health condition. Juvenility can be recovered throughout the overall skin if the functions of stem cells are
activated to the similar level as when they were young, when the original function of stem cells were protected and energy was invigorated in them. BioSpectrum, Inc. has investigated effects on stem cells targeting various natural plant extracts under the assumption that such materials would exist in nature. The BioSpectrum research team has found materials which protected and activated stem cells from the unfavourable conditions. It first decreased the number of nutrients in the in vitro cell culture system, applied UV or oxides such as H2O2, and then treated the cells with various nature-derived ingredients. After processing with countless nature ingredients, BioSpectrum discovered that very small sized vegetable peptides processed with protein catabolic enzymes could protect and activate stem cells in various harmful environments. In particular, small sized peptides obtained from peas showed an outstanding effect, and wheat peptides, soybean peptides, peptides extracted from bird nests, and apple polyphenols also showed a similar level of efficacy. Although such materials have been used in cosmetics in a similar format, peptides obtained from peas or wheat showed efficacy even in lower density when the size of peptides is smaller. In the case of apple, although the various types of polyphenols are commercialised, such effects were only shown under certain extract conditions. Pea peptide can be referred to as the optimum ingredient in terms of maintaining skin health and relieving ageing signals, by increasing the vitality of skin fibroblasts or immune cells in addition to the stem cells. Even if such ingredients have been known to be safe for a long time giving no impact on genotoxicity or skin cancer cells, they can be used as brand new materials in new product fields such as stem cell cosmetics. BioSpectrum undergoes diverse research on mechanical stress and consistent research on whitening, induction of skin melanin, anti-ageing and anti-inflammation, as well as on stem cell protectors. It plans to launch diverse new materials in the market within the next few years by completing examinations on marine biomaterials. BioSpectrum, Stand G34
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