35
-25 -20 -15 -10 -5 0
Figure 2: ILLUMISCIN® reduces the size and appearance of age spots.
The graph shows the reduction of age spots over time (n=20). A solution of 6% RAHN’s Cosmetic Active in water/ethanol was applied twice daily. The insert shows an overlay of a representative age spot on days 0 and 84.
References 1. Friguet B, Bulteau AL, Chondrogianni N, Conconi M, Petropoulos I. Protein degradation by the proteasome and its implications in aging. Ann N Y Acad Sci 2000,908:143-154.
2. Poppek D, Grune T. Proteasomal defense of oxidative protein modifications. Antioxid Redox Signal 2006,8:173-184.
3. Jung T, Bader N, Grune T. Lipofuscin: formation, distribution, and metabolic consequences. Ann N Y Acad Sci 2007,1119:97-111.
4. Noblesse E, Nizard C, Cario-Andre M, Lepreux S, Pain C, Schnebert S, et al. Skin ultrastructure in senile lentigo. Skin Pharmacol Physiol 2006,19:95-100.
5. Farout L, Friguet B. Proteasome function in aging and oxidative stress: implications in protein maintenance failure. Antioxid Redox Signal 2006,8:205-216.
6. Chondrogianni N, Gonos ES. Proteasome activation as a novel antiaging strategy. IUBMB Life 2008,60:651-655.
7. Bregegere F, Milner Y, Friguet B. The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: a handle for skin care? Ageing Res Rev 2006,5:60-90.
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0
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0
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Figure 3: Proteasome activation rejuvenates the skin. Top: At day 0, wrinkle depth was measured in four age groups (n=20 each), and a regression line was calculated to delineate age according to the wrinkle depth. Bottom: Subsequently, the age group 41-45 applied a 3% PROTEOLEA® gel twice daily, and wrinkle depth was measured again on days 14 and 28. Using the regression-line function, the age that corresponds to the measured wrinkle depth was calculated. Skin rejuvenation was determined to be 3.3 and 6.1 years within 14 and 28 days, respectively.
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