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major underlying medical problems common in this population. Laboratory clues are not covered here, but a trained integrative clinician familiar with this population will have the necessary expe- rience to evaluate the appropriate biomarkers.


1. Gastrointestinal problems a. Severe colic; reflux; failure to thrive b. Poor sleep; toe walking; peeling feet c. Strategies to put pressure on abdomen d. Frequent early infections with antibiotics and or steroids


e. Self-injurious or aggressive behaviors f. Food sensitivities; thrush; cradle cap g. Bloated/doughy abdomen; red anus, ears or cheeks


h. General look of pain i. Family history of gastrointestinal problems j. Craves carbohydrates


k. Inappropriate (drunken/maniacal) laughter


2. Mitochondrial dysfunction a. Low tone (floppy baby, poor handwriting) b. Difficulty with anesthesia/sedation for procedures


c. Constipation; drooling; ptosis d. Poor suck (unable to breastfeed); difficulty chewing or swallowing


e. Drooling f. Poor hand-eye coordination g. Seizures


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