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Innovation in profilometer- guided Raman imaging
T
he Pittcon 2017 event saw WITec introduce the next generation of its TrueSurface optical profilometer. The combination of surface analysis and Raman
spectral acquisition enables topographic Raman imaging on rough and uneven samples. One-pass simultaneous operation makes 3D Raman chemical characterisation easier and faster than before. “We established Raman topographic imaging with
purpose but the options for data
TrueSurface, and we continued to innovate,” says Dr Olaf Hollricher, MD of R&D. “The positive feedback from our customers confirms that chemical 3D surface analysis with TrueSurface is a successful concept.” With the TrueSurface option, Raman spectra are
acquired from precisely along a surface, or at a set distance from a surface. This makes the distribution of chemical components within the sample visible in three dimensions. Rough, inclined or irregularly-shaped samples can be investigated with the same ease as standard ones.
feedback of where the tumour and non-tumour regions were located were limited to looking at complicated statistical outputs or potentially flashing lights in people’s eyes,” he says. “We aimed to use the Raman output to directly control a synthesizer equation to see if the different molecular signal could be turned into different sounds, which it was.” Tis Raman spectrum output was then fed directly into a synthesizer equation to produce the tissue sounds that the team has discovered. “Te major advantage
of this technique, when combined with Raman probes, is the ability for the surgeon to maintain visual focus on the surgical procedure – as well as its ability to help to provide inter-operative diagnostics, which would hopefully enable more efficient removal of cancerous tumours,” he adds.
Analysing status of living cells Another interesting initiative is currently being coordinated by the Italian National Research Council, which is applying an RS-based approach to complement its work on the development of so-called memristor (or MEMory ResISTOR) networks. Tese state-of-the-art electrical
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Above: Horiba’s latest LabRam spectrometer
Far left: A shot of the experimental setup Silvia Caponi and her team used at the joint laboratory of the IOM-CNR and the Department of Physics and Geology in the University of Perugia
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