« SECTION TITLE
Pharmaceutical Compositions Comprising Silica Microspheres.
N. Avram, M. Shevachman, A. Ze’evi, E. Asculai, and B. Binyaminovich; US Patent # 8,920,821. December 30, 2014.
The patent describes a sustained release composition for topical application of pharmaceuticals comprising of preformed silica microspheres impregnated with benzoyl peroxide such that there is also free benzoyl peroxide in the composition. The mean microsphere size is in the range of 0.5 µm through 40 µm. The formulation composition also contains a gelling agent, a solvent, an antioxidant, a preservative, an emulsifi er, and water. Silica microspheres contain an active ingredient in the amount of 0.01% to 15% w/w.
Crystalline Freebase Forms of a Biphenyl Compound.
G. Woollam; US Patent # 8,921,396. December 30, 2014.
Therapeutic agents useful for treating pulmonary or respiratory disorders are advantageously administered directly into the respiratory tract by inhalation. Several types of inhalation devices have been developed including dry powder inhalers (DPI), metered-dose inhalers (MDI) and nebulizer inhalers. When preparing formulations for use in such devices, it is highly desirable to have a crystalline form that is neither hygroscopic nor deliquescent and has a relatively high melting point allowing the material to be micronized without decomposition. This invention provides 2 crystalline freebase forms of biphenyl compounds and their compositions.
It also describes the processes and
intermediates for preparing the crystalline freebases and methods of using them to treat a pulmonary disorder.
Stable Formulations for Lyophilizing
T erapeutic Particles.
G. Troiano, Y. H. Song, S. E. Zale, J. Wright, and C. Van Geen Hoven; US Patent # 8,916,203. December 23, 2014.
A need exists for nanoparticle therapeutics and methods of making such nanoparticles capable of delivering therapeutic levels of drugs to specifi c damaged organs and while also possessing superior storage capabilities. This patent describes a method of preparing a reconstituted lyophilized composition suitable
for parenteral
administration, comprising of polymeric nanoparticles containing a therapeutic agent, hydroxypropyl beta- cyclodextrin (7% to 12% w/w), and a sugar (4% to 6% w/w). The reconstituted lyophilized composition has a concentration of 10 to 100 mg/mL of the polymeric nanoparticles. Freeze drying a nanoparticle suspension creates a product for reconstitution with superior storage stability. This system enables a targeted delivery to a specifi c diseased tissue.
Aerosol T erapy Device with High Frequency Delivery.
S.T. Immel; US Patent # 8,899,230. December 2, 2014.
This patent describes an aerosol therapy device to deliver active ingredients to paranasal sinuses with a pulsating fl ow of air. The variation in the external air pressure causes the ostia (opening) of the recipient’s sinuses to oscillate in and out, allowing an increased gas exchange via the ostia. The aerosol can be generated by a pneumatic or jet nebulizer-type device or a thermal vaporizer or by an ultrasonic device. The pulsated air generator is triggered when the patient breaths.
The aerosol particles have
the mass-median diameter from about 0.5 µm to about 150 µm, and the pulsating air fl ow pulsates at a frequency from about 300 Hz to about 4000 Hz.
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