« INSIDER INSIGHT
Detectability is the key characteristic of the commodity chemicals proposed for use as taggants, but they have other distinguishing features as well: they can be spread out into thin fi lms, they adhere well, their viscosity is appropriate, and they cure quickly. When considered together, these properties make the
tagging solution fl exible eff ective for brand protection.
Spectral Results The spectra in Figure 1A show specifi c diff erences between tagged and untagged paperboard, with the red showing anti- counterfeiting taggant, clearly diff erentiated from the untagged paperboard shown in black.
Experiment 2
Coating For Pharmaceutical Aluminum Vial Tops •
• •
Taggant had to meet colorfast specifi cation
Taggant had to meet autoclaving specifi cation
Covert taggant mix applied on aluminum shells at 3 levels of thickness: 3 mil, 5 mil, and 10 mil
and cost- • •
Taggant had to meet irradiation specifi cation
Several UV cured taggants 3met specifi cations
Figure 2 shows the NIR spectrum of untagged, tagged, autoclaved, and irradiated aluminum vial shells (red). The taggant absorption bands can be seen as distinct features and are discernibly diff erent from the spectrum of the respective untagged aluminum shells (black).
NIR spectroscopy was used to distinguish the presence or absence of taggants from their substrates.
Additional factors include the
properties of the chemicals to be spread out into thin fi lms, their adhesive properties, their viscosity, and their UV curing properties.
Conclusions
Commodity chemicals can be used for the purpose of formulating taggants for coating packaging and product components. The formulations must exhibit a range of properties that are required for the explicit purpose of remaining undetected in the visible spectrum but exhibit specific absorption bands in the NIR spectrum that allow detection when an NIR spectrometer is used to locate the presence of specific absorption bands arising only from the formulated coating material.
The covert nature of the taggants makes it hard for counterfeiters to detect their presence, much less
copy them. The
use of hand-held instruments for field authentication makes it easier to test more, protect more, and better target prevention, security, and forensic resources.
References 1.
2.
Burns DA, Ciurczak EW, eds. Handbook of Near-lnfrared Analysis, Third Edition. Boca Raton London New York: CRC Press, Taylor & Francis Group; 2008.
Coates J. A review of new small-scale technologies for near infrared measurements. Am Pharm Rev. 2014;17(4):74-78.
Author Biography
Gary E. Ritchie is Director of Scientifi c Aff airs for InfraTrac, Inc., located in Silver Spring, MD.
Gary is an internationally recognized
Figure 2. NIR spectrum of untagged, tagged, autoclaved, and irradiated aluminum vial shells (Red).
expert in pharmaceutical analysis, regulatory compliance, laboratory management, design quality, and process analytical technology (PAT) using spectroscopic methods including near-infrared and multivariate analysis. Gary has 19 years of industry experience with increasing responsibility, 5 years of policy experience, and ongoing consulting experience in the pharmaceutical and biopharmaceutical industry. He was Scientifi c Fellow for Process Analytical Technology with the United States Pharmacopeia (USP) and Liaison to the General Chapters, Pharmaceutical Waters and Statistics Expert Committees from 2003 through 2008. As a USP in-house expert on the FDA Process Analytical Technology and Quality by Design Initiative, he was responsible for over 30 Pharmacopeial chapter revisions that incorporated and refl ected the revisions by the FDA on the 21st Century cGMP Initiatives. He also led collaborations on several FDA, USP, and industry projects that resulted in several Pharmacopeial standards. Gary has more than 25 peer-reviewed papers and book chapter contributions, 5 issued patents, and numerous industry journal articles, and has been invited to give many conference and symposia presentations worldwide. He was President of The Council for Near-Infrared Spectroscopy (2012–2014). Gary holds a Master's of Science and Bachelor of Arts degrees in Biology from the University of Bridgeport.
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