statistic, especially since Dr. Alessio Fasano, a pediatric gastroenterologist and research scientist who leads the Center for Celiac Research & Treatment at Massachusetts General Hospital, in Boston, found that the gluten in wheat leads to the production of zonulin in the gut. Zonulin increases the permeability of the intestinal wall, allowing proteins to leak from the gut into the bloodstream, explains Perlmutter. These proteins, which would normally remain within the digestive system, then challenge parts of the immune system, the macro fascia and certain other types of white blood cells that increase production of infl ammation-related chemicals. “Zonulin is the cornerstone of diseases characterized by infl ammation in the brain—Alzheimer’s, autism, Parkinson’s and attention defi cit disorders—as well as autoimmune diseases,” advises Perlmutter. Fasano’s research shows that such a reaction to zonulin is present in 100 percent of humans—not just in the 1.8 percent of the population that have celiac disease or 30 percent that are gluten sensitive. “A hallmark of what I term grain brain is that brain dysfunction is predicated on the infl ammation from consumption of gluten, as well as the long chains of sugar molecules known as carbohydrates,” says Perlmutter. “This includes fruit, which also was consumed in limited quantities by our ancestors.” He cites a published analysis by Loren Cordain, Ph.D., author of The Paleo Diet. A diet high in carbohydrates has been directly related to
atrophy, or brain shrinkage, according to a recent German study by University of Bonn researchers, published in Neurology. A blood test for hemoglobin A1C, the standard laboratory measurement to assess average blood sugar, is frequently used in studies that correlate blood sugar control to disease processes like Alzheimer’s, mild cognitive
“A hallmark of what I term grain brain is that brain
dysfunction is predicated on the infl ammation from consumption of gluten, as well as the long chains of sugar molecules known as carbohydrates.”
~ Dr. David Perlmutter
impairment and coronary artery disease. The researchers concluded that elevated hemoglobin A1C is directly associated with brain shrinkage, says Perlmutter. He further notes, “The function
of the brain, which is 60 to 70 percent fat and maintained by the fats you consume, depends on its environment.” Grain Brain recommends a diet that’s aggressively low in carbohydrates (60 grams per day) and bountiful in supportive brain fats. These include extra-virgin olive oil, sesame oil, coconut oil, ghee, almond milk, avocados, olives, nuts, nut butters, cheese and seeds such
as fl axseed, sunfl ower, pumpkin, sesame and chia. It is also rich in above-ground vegetables such as kale, broccoli, spinach, caulifl ower, Brussels sprouts and salad greens, while relatively low in below-ground vegetables like beets, carrots and potatoes, which are higher in carbohydrates. It also calls for reduced fruit consumption. “Having two to four servings of fruit every day, based on America’s present food pyramid, is not helpful. More in line with avoiding brain drain is an apple or a handful of berries, or about 100 calories worth of any fruit. In my opinion, the pyramid needs to be stood on its head,” advises Perlmutter. “We should eat a diet similar to what our ancestors survived on for 2.6 million years and reprogram support of our genetic destiny for the better.”
Dr. David Perlmutter is a board-certifi ed neurologist, Fellow of the American College of Nutrition and author of Grain Brain. For more information on his 2013 PBS Grain Brain series, visit
DrPerlmutter.com.
Linda Sechrist is a senior staff writer for Natural Awakenings. Visit
ItsAllAboutWe.com for the recorded interview.
November 2013 33
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