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DDW drug discovery world the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan


Robert@rjcoms.com


Consultant Editor Dr Roger Brimblecombe


Contributing Author Dr John Comley


Publishing Manager Damian Doherty Damian@rjcoms.com


Design & Production Melissa Chadderton


melissa@rhubarbcreative.demon.co.uk


Circulation & Production Controller Charles Davenport Charles@rjcoms.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr David Clough Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8ET, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


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© 2013 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.


contents


VOLUME 14 ISSUE 2 ● SPRING 2013 Introduction


Dr Roger Brimblecombe Consultant Editor


Therapeutics


Challenges and Opportunities in the Treatment of Rare Diseases Dr Philip J. Vickers


Genomics


Realising the Genome’s Potential in the Context of the Living Cell Dr Amr Abid


Genomics


DNA Sequencing – Towards the Third Generation and Beyond Andrew Szopa-Comley


Flow Cytometry


Evolution of Flow Cytometry as a Drug Screening Platform Dr Rob Jepras and Dr Steve Ludbrook


Screening


Adoption of High Content Screening at HTS Laboratories William Downey and Dr Jennifer Hartigan


Drug Development


An Automated Approach to Solving Pharma’s Cardiac Toxicity Conundrum Beppy van de Waart, Dr Walter Westerink and Dr Nuria Piñeiro


Business


Addressing the Economic Downturn Through Lab Instrument Rental Dr John Comley


Drug Discovery


Chemical Space, High Throughput Screening and the World of Blockbuster Drugs Dr Hakim Djaballah


7 9


18 29 43 51


60 67 73


Front cover illustration courtesy of David Mack/Science Photo Library Drug Discovery World Spring 2013 5


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