Contents
DDW drug discovery world the quarterly business review of drug discovery & development
Publisher and Editor-in-Chief Robert Jordan
Robert@rjcoms.com
Consultant Editor Dr Roger Brimblecombe
Contributing Author Dr John Comley
Publishing Manager Damian Doherty
Damian@rjcoms.com
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melissa@rhubarbcreative.demon.co.uk
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Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8ET, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail:
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contents
VOLUME 14 ISSUE 2 ● SPRING 2013 Introduction
Dr Roger Brimblecombe Consultant Editor
Therapeutics
Challenges and Opportunities in the Treatment of Rare Diseases Dr Philip J. Vickers
Genomics
Realising the Genome’s Potential in the Context of the Living Cell Dr Amr Abid
Genomics
DNA Sequencing – Towards the Third Generation and Beyond Andrew Szopa-Comley
Flow Cytometry
Evolution of Flow Cytometry as a Drug Screening Platform Dr Rob Jepras and Dr Steve Ludbrook
Screening
Adoption of High Content Screening at HTS Laboratories William Downey and Dr Jennifer Hartigan
Drug Development
An Automated Approach to Solving Pharma’s Cardiac Toxicity Conundrum Beppy van de Waart, Dr Walter Westerink and Dr Nuria Piñeiro
Business
Addressing the Economic Downturn Through Lab Instrument Rental Dr John Comley
Drug Discovery
Chemical Space, High Throughput Screening and the World of Blockbuster Drugs Dr Hakim Djaballah
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Front cover illustration courtesy of David Mack/Science Photo Library Drug Discovery World Spring 2013 5
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