Genomics
Figure 12: The Miseq from Illumina a fully integrated personal sequencer
Figure 13: The HiSeq 2500 from Illumina is ready for any application, any sample size, today
chemistry enhancements to HiSeq® 2500, its next- generation system capable of sequencing an entire genome in approximately 24 hours. With support of paired 250 base pair read lengths in rapid run mode, HiSeq 2500 will be able to generate up to 300Gb in rapid mode with sample to data in less than three days. Illumina also introduced a novel library prep method and analysis algorithm, enabled by its recent acquisition of Moleculo, Inc. It will produce synthetic read lengths up to 10Kb at an extremely low error rate, allowing for more comprehensive coverage and accurate genotyping
of clinically significant genes and new applications. Interest in MiSeq®, Illumina’s benchtop sequencer, continues to grow as the company shared an updated product roadmap with a path to 15Gb of output. The company’s cloud-based data analysis, storage and sharing platform, BaseSpace, also con- tinues to expand. BaseSpace Apps, an applications store for BaseSpace, has grown to more than 100 independent developers who are bringing a wide range of analysis tools to the user base. Beyond these core updates, Illumina recently announced it has acquired Verinata Health, a leading provider of non-invasive prenatal tests for the early identifica- tion of foetal chromosomal abnormalities. This acquisition builds on Illumina’s acquisition in 2012 of BlueGnome, a leader in cytogenetics and in vitro fertilisation, establishing the company as a leader in genomic-based diagnostics and advancing repro- ductive health (Figures 12 and 13).
Figure 14: The Ion PGM™ and Ion Proton™ Systems from Ion Torrent (Lifetech) deliver fast, simple, scalable next-generation sequencing that any lab can afford
34
Ion Torrent (
www.iontorrent.com) has pioneered an entirely new approach to sequencing using semiconductor technology and simple chemistry. Ion Torrent sequencers deliver faster, simpler sequencing at a fraction of the cost of other sequencers on the market, making sequencing more accessible for all labs. Ion Torrent has recent- ly released 400 base sequencing on the Ion PGM™ System for improved assembly of de novo micro- bial sequencing, making it the only benchtop sequencer to offer long read sequencing as a cost- effective option for routine use. The highly multi- plexed Ion AmpliSeq™ Targeted Selection Technology, which offers targeted human DNA
Drug Discovery World Spring 2013
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80