well
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supplements and carefully check labels for EPA amounts. Folate + antidepressants. High-dose L-methylfolate, the natural form of folate, can make SSRI antidepressants more effective and is even an FDA-approved depression treatment, says Galland. Consult your doctor before considering a folate supplement of 400–800 mcg daily, Galland says. Te SSRI studies used 5–15 grams L-methylfolate daily. N-acetyl cysteine (NAC) + blood pressure and nitrate drugs. Te antioxidant NAC is a precursor to glutathione, a major cell detoxifier. It also promotes healthy, flexible artery walls. Clinical studies show that NAC may improve the effectiveness of blood pressure–lowering drugs called angiotensin- converting enzyme (ACE) inhibitors, as well as nitrate drugs prescribed for angina, Galland says. Taking NAC also counteracts liver damage that can result from chronic use of acetaminophen, which depletes the liver of glutathione, says Rountree.
Negative interactions St. John’s wort. Te research is mixed about whether Hypericum perforatum may effectively treat short-term, mild-to- moderate depression. But it does affect enzymes in the liver and intestine, thus significantly altering blood levels of about 30 different drugs. In the case of birth
control pills, for instance, the herb accelerates hormone breakdown and can reduce the effective dose by as much as half, causing the drug to fail, says Galland. Ginkgo, garlic, and ginseng. Te anticoagulant properties in these herbs can promote cardiovascular health but also may increase bleeding risk for heart patients taking warfarin. If you are taking warfarin, ask your doctor before starting any of these herbs or aspirin. Calcium. Although helpful when paired with metformin, for example, this mineral can bind with other drugs to decrease absorption. For instance, it can reduce the effectiveness of many antibiotics, as well as thyroid medications and L-dopa drugs used to treat Parkinson’s disease. Tis may be of special note to older women: Two-thirds of women over 60 now take calcium supplements, up from 28 percent in the early 1990s, according to the CDC. In large doses, magnesium may have the same effect, says Cass. Take both minerals at a different time than these types of drugs, she recommends.
Although gratefully prescription-free at present, Delicious Living senior editor Susan Enfield plans to do homework before anyone in her family starts taking a doctor- recommended drug.
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june 2012 | deliciousliving 33
© 2007-2012 Waterwise Inc
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