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research round-up
COLLAGEN INDUCTION THERAPY FOR THE TREATMENT OF UPPER LIP WRINKLES
Fabbrocini G, De Vita V, Pastore F et al. J Dermatolog Treat 2012; 23(2): 144–52
many people due to their perceived unsightly appearance. Several options are available today for their treatment. A new therapeutic option, called collagen induction therapy (CIT), seems to be effective and safe for the treatment of upper lip wrinkles. The aim of this study is to demonstrate the efficacy and safety of CIT in the treatment of upper lip wrinkles. Ten female subjects,
U aged 50–65 years old, with upper lip wrinkles were PPER LIP WRINKLES ARE VERY common and impair the quality of life of
enrolled. Each patient was treated with a specific tool in two sessions. Using a digital camera, photographs were taken of all the patients to evaluate the depth of the wrinkles and a silicon-print technique was used to obtain a microrelief impression of the wrinkles. Data of the cutaneous casts were analyzed by computerized image analysis. Analysis of the patientsÕ photographs, supported by the sign test, and of the degree of irregularity of the surface microrelief, supported by Fast Fourier Transform and by wrinkle image processing, showed that, after only two sessions, the wrinklesÕ severity grade in most patients was greatly reduced. The present study confirms CIT as an effective and safe technique to improve upper lip wrinkles.
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RATIONAL DISCOVERY AND DEVELOPMENT OF A MITOCHONDRIA-TARGETED ANTIOXIDANT BASED ON CINNAMIC ACID SCAFFOLD
Teixeira J, Soares P, Benfeito S et al. Free Radic Res 2012; 46(5): 600–11
A NOVEL MITOCHONDRIA-TARGETED by attaching the
antioxidant (TPP-OH) was synthesized natural hydrophilic
antioxidant caffeic acid to an aliphatic lipophilic carbon chain containing a triphenylphosphonium (TPP) cation. This compound has similar antioxidant activity to caffeic acid as demonstrated by measurement of DPPH/ABTS radical quenching and redox potentials, but is significantly more hydrophobic than its precursor as indicated by the relative partition coefficients. The antioxidant activity of both compounds was intrinsic related to the ortho-catechol system, as the methoxylation of the phenolic functions, namely in TPP-OCH3 and dimethoxycinnamic acid, gave compounds with
negligible antioxidant action. The
incorporation of the lipophilic TPP cation to form TTP-OH and TPP-OCH3 allowed the cinnamic derivatives to accumulate within mitochondria in a process driven by the membrane potential. However, only TPP-OH was an effective antioxidant: TPP-OH protected cells against H2
O2 and linoleic acid
hydroperoxide-induced oxidative stress. As mitochondrial oxidative damage is associated with a number of clinical disorders, TPP-OH may be a useful lead that could be added to the family of mitochondria-targeted antioxidants that can decrease mitochondrial oxidative damage.
56 ❚ April/May 2012 |
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