ARTICLE | VOLUMISATION TECHNIQUES | SKIN BOOSTING
USING NASHA-SPECIFIC PRODUCTS
The concept of skin boosting using stabilised hyaluronic acid can create a long-lasting improvement in the skin.
Marina Landau reviews the evidence to support this theory
ABSTRACT Skin ageing is accompanied by a significant change in the dermal content of collagen and hyaluronic acid. It has been shown that enrichment of the dermis by injectable stabilised hyaluronic acid creates a long-lasting improvement in skin quality. Following this clinical observation, a novel concept of skin boosting has been developed. Specifically designed skin boosters are effective and safe for this indication. This article presents the theoretical basis and the clinical application of skin boosting using stabilised hyaluronic acid.
MARINA LANDAU, MD, is Dermatologist, Wolfson Medical Center, Holon, Israel
email:
mlandau@zahav.net.il S
KEYWORDS dermal rejuvenation, volumisation, collagen, hyaluronic acid
40 ❚
KIN AGEING IS CHARACTERISED BY morphologic changes and functional alterations. Of greater clinical importance is photoageing, the superposition of chronic sun damage on intrinsic ageing. Briefly, chronologically aged skin appears dry and
pale with fine wrinkles, displaying a certain degree of laxity and a variety of benign neoplasms. In contrast, photoaged skin is also irregularly pigmented and sallow, often displaying deep furrows in addition to fine wrinkling, or (in fair-skinned persons) severely atrophic, with multiple telangiectasias and a variety of premalignant lesions such as actinic keratoses. Loss of skin firmness is one of the primary manifestations of skin ageing. Both intrinsic and extrinsic factors contribute to this event. Sun exposed areas, such as the face and dorsum of the hands, are the first to clearly demonstrate the decline in skin elasticity. On the molecular level, viscoelastic properties of the skin are attributed to collagen and elastic fibres1
. The April/May 2012 |
prime-journal.com
reduction of fibrillar collagen (types I and III) is a characteristic feature of chronologically aged skin and is enhanced in photodamage2
. During natural or
chronological ageing of the skin, collagen-degrading matrix metalloproteinases are gradually increased3
.
Their activity is also up-regulated acutely in response to UV radiation4
. Furthermore, in photodamaged skin there is a
sustained down-regulation of collagen synthesis relative to that which occurs in healthy, sun-protected skin. As a result of this acceleration in degradation and the diminished ability to produce new collagen and elastin, the viscoelasticity of the skin decreases. Clinically, skin tonicity and firmness decrease. On the cheeks Ô in-motionÕ wrinkles can be seen. If acne scars are present, they become more visible. A decrease in endogenous hyaluronic acid is another
aspect of skin ageing. Normally, hyaluronic acid is located in both the dermis and epidermis, with biological functions differing according to the location. While in the epidermis, hyaluronan serves mainly in signal transmission, in the dermis it has antioxidative functions, can activate dermal fibroblasts, and contributes to the skinÕs water-holding ability. The depletion of hyaluronic acid in the dermis results in a reduced ability to bind water and contributes to skin roughness, sagging, and wrinkling. Supplementation of the skin with collagen, elastin and
hyaluronic acid seems the most logical approach to skin rejuvenation. Percutaneous penetration is a complex
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84