| AESTHETIC SOLUTIONS | ARTICLE FIBROSIS AND GRANULOMA
HYALURONIDASE TO TREAT HA EXCESSES,
Philippe Deprez and Evgenyia Ranneva discuss the problems that can arise following treatments using hyaluronic
acid, and how hyaluronidase can work to rectify the problem
ABSTRACT Hyaluronidase is an enzyme that specifically dissolves hyaluronic acid polymers. In the past it has been largely used for undoing cellulitis fibrosis and more recently, for dissolving hyaluronic acid filler excesses of granulomas. The use of hyaluronidase is very simple and comprises the injection of a sterile dissolution of the hyaluronidase powder directly inside the problem area to be treated. An allergy test is absolutely essential before every injection session, since hyaluronidase is an enzyme, an exogenous protein. Results can be seen very quickly and are definitive.
The side-effects of cross-linked
hyaluronic acid have
mainly been described in terms of over-
correction, infection or granuloma.
PHILIPPE DEPREZ , MD, PHD, is Director, Clinica Hera, Empuriabrava, Spain; and EVGENYIA RANNEVA, MD, PHD is Dermatologist, Empuriabrava, Spain, and Russia.
email:
phd@estetik.com;
jane@estetik.com
in the face, hands and body. Non-cross-linked hyaluronic acids are used in order to refill and rehydrate the dermis, and are also often associated with biorevitalisation actives in order to combine the hydration effect with stimulation of the normal metabolic skin processes, or to help other molecules to widely diffuse into the dermis or increase the penetration of drugs. The side-effects of cross-linked hyaluronic acid have
H hyaluronic
KEYWORDS hyaluronic acid, hyaluronidase, granuloma, necrosis, fibrosis
mainly been described in terms of over-correction, infection or granuloma. Other rare cases have been described, including local necrosis as a result of vascular compression or lung embolism after vaginal injection. All kinds of side-effects are uncommon, making hyaluronic acid safe to use as an office treatment. Hyaluronidase is a specific enzyme, able to cut the acid polymer;
it is used in cases of
over-correction, fibrosis, granuloma, and also for reducing the risk of an eventual vascular compression, which could lead to skin necrosis.
prime-journal.com | April/May 2012 ❚ 31
YALURONIC ACID IS A NATURAL polymer actually considered as the simplest and safest filler agent. Cross-linked hyaluronic acid is widely used to treat facial wrinkles and folds, augment the lips, and for volumisation
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