Gene rearrangements suggest specific form of non small-cell lung cancer


small-cell lung cancer (NSCLC). These rearrangements occur in a


A NEW MOLECULAR test identifies the presence of gene rearrangements associated with a specific form of non-


gene known as anaplastic lymphoma kinase (ALK). The Vysis ALK Break Apart FISH probe kit uses fluorescence in situ hybridization (FISH) technology to detect rearrangements of the ALK gene on the 2p23 chromosome in tumors. FISH technology can identify whether too many, or too few, copies of a particular gene are present in the body’s cells, or whether certain genes have rearrangements that play an active role in disease progression. Also known as the Abbott ALK test, the new assay will be used for testing, research,


and to support evaluations of new therapies in multinational government funded studies. It is commercially available in the United States and CE-Mark countries only. Lung cancer is the world’s leading cause


of cancer death with more than 1.6 million new cases diagnosed each year. About 85% of lung cancer patients have the non-small- cell type, and usually they are diagnosed with advanced disease with a very low survival rate. About 3% to 5% of these patients are thought to have ALK gene rearrangements and have been shown to respond to therapies that block the ALK pathway. ■ Source: Labmedica.com


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Thermo Fisher Scientific launches embedding system to maximize laboratory productivity


THERMO FISHER SCIENTIFIC Inc., the world leader in serving science, has introduced the Thermo Scientific HistoStar embedding system to deliver improved user comfort and productivity during the embedding process. The first embedding center to incorporate a continuously adjustable paraffin dispenser paddle for user specific sample sizes, the HistoStar can accommodate all cassette sizes and accept baskets from any tissue processor in its large-capacity specimen drawer. Its five- litre paraffin reservoir and large area cold plate have also been designed to maximize productivity in the busiest of laboratories. The new HistoStar embedding system


incorporates an ergonomic design with smooth and insulated contact points for a cool and comfortable workspace, ensuring users can focus on the embedding process without discomfort or clutter.Combined with patented cool LED lighting for improved specimen visibility, the HistoStar also provides five levels of illumination for both the specimen and accessory areas, eliminating the need for remote lamps and bulb replacement. With an intuitive touch-screen design for


parameter controls and programmable ‘sleep’ mode for reduced energy consumption, the HistoStar is the only embedding center with a built-in Paratrimmer©


for the removal of


excess paraffin during specimen preparation - once again removing the need for additional equipment. The robust design of the Thermo Scientific HistoStar minimizes moving parts, reducing wear and service requirements and ensuring dependable performance over the years. A full accessory range also enables users to optimize their system with tools such as heated forceps, magnifier and


foot pedal. For further information, please visit www.thermo.com/pathology. ■


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MedLab Issue 3 2011


9


NEWS


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