| research round-up
than those 19 control mice bearing melanoma without nsPef. Histopathology follow-up showed that melanoma did not recur to the primary injection place after complete elimination. compared with the control tumor, nsPef-treated tumors present decreased micro-vessel density in a time-course manner in this survival study. Treatment with nsPef caused continuous histopathological changes in melanomas, eliminated melanoma without recurrence at the primary site and prolonged animal survival time by inhibiting tumor blood supply and leading to tumor infarction. Thus, nsPef could be applied in a non-ionizing therapeutic approach, without other agents, to locally treat tumors within a defined boundary.
PHOTOCHEMICAL STABILITY OF LIPOIC ACID AND ITS IMPACT ON SKIN AGEING
Matsugo S, Bito T, Welford H, Konishi T. Free Radic Res 2011; [Epub ahead of print]
the mitochondrial multi-enzyme complex and thus plays an important role in energy metabolism. currently, it is attracting attention as a nutritional supplement because of its unique antioxidant properties and broad spectra of cellular functions. skin protection from photodamage and ageing is one of the functional applications of la. Medical and cosmetic application has been widely realized in the world. However, la has a unique structure bearing a distorted five membered 1, 2-dithiolane ring, making it quite vulnerable to uv radiation. The present article briefly reviews skin ageing from the viewpoint of
i
T is Well knoWn THaT α-liPoic acid (la) functions as an essential co-factor of
oxidative stress and sun exposure and analyses the photochemical properties of la. it also discusses the effect of la to cellular signalling and its adequate applications to treat skin ageing caused by oxidation. data presented in this review suggest that la is a powerful anti-ageing agent under the appropriate usage.
EFFECT OF AN ORAL GLUCOSE LOAD ON PTH, 250HD3, CALCIUM, AND PHOSPHORUS HOMEOSTASIS IN POSTMENOPAUSAL WOMEN
Polymeris AD, Doumouchtsis KK, Giagourta I, Karga H. Endocrine Research 2011; 36(2): 45–52
serum calcium declines and parathyroid hormone (PTH) rises during an oral glucose load. However, there is not a general agreement in this regard. This study was carried out to evaluate the effects of an oral glucose load on calcium and phosphorus homeostasis in postmenopausal women along with serum insulin, PTH, and 250Hd3 changes. Patients and methods. after an overnight fasting, an oral glucose tolerance test was performed in 50 postmenopausal women; and glucose, insulin, PTH, and d3 were measured at baseline and every 30 min during the 2 hours of the test. Results. serum glucose and insulin increased as expected and reached their peak values at 60 and 90 min, respectively. PTH and phosphorus decreased significantly and the maximum decline was observed at 30
P
revious sTudies ParTicularly in children and neonates have shown that
and 120 min after glucose load (p < 0.0001), respectively. serum calcium, magnesium, and d3 levels showed no significant changes at any time measured. serum PTH values had a significant negative correlation with glucose and insulin values (p = 0.026 and p = 0.031, respectively). serum d3 also correlated negatively with glucose (p = 0.002). Conclusion. our study shows that an oral glucose load induced hyperglycemia/hyperinsulinemia promotes a significant decline in serum PTH and phosphorus levels without changes in calcium or 250Hd3 in postmenopausal women.
prime-journal.com | July 2011
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