ARTICLE | dermatology | treatment. mixed blue–red light daily for 12 weeks
improved inflammatory acne significantly more than daily topical benzoyl peroxide (76% versus 60%; P<0.006)8
option for acne patients who are recalcitrant to standard acne treatments and poor candidates for systemic retinoids49
.
Conclusions to date, there is no consensus with regard to how to perform Pdt for acne therapy. a systematic review of the trials using Pdt for acne concluded that most trials showed a benefit from using Pdt compared with light therapy alone. multiple treatments appeared to be superior to single treatments, especially at longer follow-up periods. limitations of existing studies include lack of controls, qualitative non-blinded methods, variable light dosimetry, variability of incubation time of the topical agent, small sample sizes, and short follow- up periods. also, patients may experience severe, short- term side-effects, including pain22, 50
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. It is proposed that Pdt is a useful therapeutic New formulations of topical agents and new ala
derivatives for use in Pdt are in the pipeline. liposome-encapsulated 0.5% ala spray with IPl was effective in reducing inflammatory facial acne in asian populations, with low post-treatment photosensitivity51
.
lower concentrations of mal (2-, 4- and 8%) are being studied in phase I and phase II clinical trials for acne treatment. also, the hexyl ester of ala has been approved for bladder cancer treatment in europe, but there are no studies of its effect on acne as yet52
. Further studies with regard to the use of Pdt for acne
are warranted to provide data on the identification of optimal treatment parameters and the appropriate selection of light sources, so as to maximise clinical efficacy with a favourable tolerability profile.
Declaration of interest None
July 2011 |
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