THURSDAY, JULY 22, 2010
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R If you have type 2 diabetes, take steps to help control your blood sugar.
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Talk to your doctor aboutloweringblood sugarlevels.Talktoyourdoctorabout JANUVIA. If JANUVIA is right for you, start today with a free 30-day trial supply.*
JANUVIAworks to lower blood sugar in 2ways.Talk to your doctor about JANUVIA today.
Increases Insulin
Decreases Sugar Made In Liver
• It’s a once-daily prescription pill that helps your body increase the insulin made in your pancreas and decrease the sugar made in your liver. • Along with diet and exercise, JANUVIA helps lower blood sugar levels in adults with type 2 diabetes. • JANUVIA is not likely to cause weight gain.
JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA.
Selected Risk Information About JANUVIA: Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you’ve ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.
Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away.
If you take JANUVIA with another medicine that can cause low blood sugar (hypoglycemia), such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea medicine or insulin may need to be lowered while you use JANUVIA. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heart beat, sweating, and feeling jittery.
Your doctor may do blood tests before and during treatment with JANUVIA to see how well your kidneys are working. Based on these results, your doctor may change your dose of JANUVIA. The most common side effects of JANUVIA are upper respiratory tract infection, stuffy or runny nose and sore throat, and headache.
Call 1-888-JANUVIA or visit
Januvia.com. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see the Medication Guide below and discuss it with your doctor.
Having trouble paying for your Merck medicine? Merck may be able to help.
www.merck.com/merckhelps
JANUVIA is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. Copyright©2010 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved. 20950120(30)(400)-JAN
*Terms andconditionsapply.Pleasesee below. Eligible patients may receive a free 30-day trial supply of JANUVIA.
1. Bringthisvoucher to your next appointment.Ask your doctor aboutJANUVIA. 2. Getafree30-day trialsupplyofJANUVIA if your doctor says it’s rightfor you. No purchase is required. Not valid for refills. JANUVIAisaprescriptionmedication. Only your health care provider candecideifJANUVIA is rightfor you. Howthisvoucher works: •Thisvoucher canbeused1timebeforethe expiration date. •Toreceive your free 30-day trialsupplyofJANUVIA,takethisvoucher with your validsignedprescriptiontoany participatingeligibleretailpharmacy (certain restrictions apply). •There is no requirementtopurchaseany productorservice to receive your free 30-day trialsupplyofJANUVIA. •Restrictionsapply. Please see Terms and Conditions. • Expiration Date: 7/31/2011 Prescriber To initiate a free 30-day trial supply for an appropriate patient, you should: • Read the Prescribing Information before prescribing JANUVIA. •Writeaprescriptionfor up to 30 tabletsofJANUVIA.Nosubstitutions arepermitted. •Refillsare notrequiredand thereare no requirements to purchase anyproduct or servicetouse this voucher. If youwant your patienttocontinuetakingJANUVIA beyond thefree trialperiod, please writeaseparate prescription based on your recommended therapy.
• Fill in thedoseonthisvoucher. •Givethe validsignedprescriptionand this vouchertothe patient. •Eligiblepatients cantakethisvoucher andthe prescription to anyparticipating eligible retail pharmacy to receive theirfree 30-day trialsupply. •For additional copies of thePrescribing Information,call800-672-6372, visit
Januvia.com,orcontact your Merckrepresentative. Pharmacist •Only1voucher maybeused perpatient. Vouchermay notbetransferredtoanother patient. •There is no requirementfor patienttopurchaseany productorservice andrefillsare notrequired. •Pleaseensurethatthe medication anddosagestrengthselectedmatch themedicationand dosage strength on theprescription.
JANUVIA is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. Copyright © 2010 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved.
Medication Guide JANUVIA® (jah-NEW-vee-ah) (sitagliptin) Tablets
Read this Medication Guide carefully before you start taking JANUVIA and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. If you have any questions about JANUVIA, ask your doctor or pharmacist.
What is the most important information I should know about JANUVIA?
Serious side effects can happen in people taking JANUVIA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Certain medical problems make you more likely to get pancreatitis. Before you start taking JANUVIA: Tell your doctor if you have ever had • pancreatitis • stones in your gallbladder (gallstones) • a history of alcoholism • high blood triglyceride levels
Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.
What is JANUVIA?
• JANUVIA is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.
• JANUVIA is not for people with type 1 diabetes. • JANUVIA is not for people with diabetic ketoacidosis (increased ketones in your blood or urine).
• If you have had pancreatitis (inflammation of the pancreas) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JANUVIA.
• It is not known if JANUVIA is safe and effective when used in children under 18 years of age.
Who should not take JANUVIA? Do not take JANUVIA if:
• you are allergic to any of the ingredients in JANUVIA. See the end of this Medication Guide for a complete list of ingredients in JANUVIA. Symptoms of a serious allergic reaction to JANUVIA may include: • rash • raised red patches on your skin (hives) • swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing
What should I tell my doctor before taking JANUVIA? Before you take JANUVIA, tell your doctor if you: • have or have had inflammation of your pancreas (pancreatitis). • have kidney problems. • have any other medical conditions.
• are pregnant or plan to become pregnant. It is not known if JANUVIA will harm your unborn baby. If you are pregnant, talk with your doctor about the best way to control your blood sugar while you are pregnant.
Pregnancy Registry: If you take JANUVIA at any time during your pregnancy, talk with your doctor about how you can join the JANUVIA pregnancy registry. The purpose of this registry is to collect information about the health of you and your baby. You can enroll in this registry by calling 1-800-986-8999.
• are breast-feeding or plan to breast-feed. It is not known if JANUVIA will pass into your breast milk. Talk with your doctor about the best way to feed your baby if you are taking JANUVIA.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
How should I take JANUVIA? • Take JANUVIA 1 time each day exactly as your doctor tells you. • You can take JANUVIA with or without food.
• Your doctor may do blood tests from time to time to see how well your kidneys are working. Your doctor may change your dose of JANUVIA based on the results of your blood tests.
• Your doctor may tell you to take JANUVIA along with other diabetes medicines. Low blood sugar can happen more often when JANUVIA is taken with certain other diabetes medicines. See “What are the possible side effects of JANUVIA?”
• If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses of JANUVIA at the same time.
• If you take too much JANUVIA, call your doctor or local Poison Control Center right away.
• When your body is under some types of stress, such as fever, trauma (such as a car accident), infection or surgery, the amount of diabetes medicine that you need may change. Tell your doctor right away if you have any of these conditions and follow your doctor’s instructions.
• Check your blood sugar as your doctor tells you to.
•Byacceptingthisvoucher,you agree to theterms hereof. • No universal claim forms will be processed.
Terms and Conditions •Thisvoucher is validfor1free 30-day trialsupplyofJANUVIA. •Limit1voucher perpatientfor thedurationofthe program. •Valid for 1-time useonly. Free trialoffer is validonlyfor up to 30 tabletsofJANUVIA.Nopurchaseisnecessary.Refillsare notrequired. •Thisvoucher is nottransferable.Nosubstitutions arepermitted.Cannotbecombinedwithany otherfree trial, coupon,discount, prescription savings card, or other offer. • This voucher is not insurance. •Youmust be 18 yearsorolder to redeemthis voucher. Patient, pharmacist,and prescriber agree nottoseekreimbursement for allorany part of thebenefit receivedbythe patientthrough this offer.The free trialsupplyofJANUVIA cannot be used toward anyout-of-pocket costsunder anyplan(such as true out-of-pocketexpense [TrOOP]).
•Thisvoucher canbeused only by eligible US residentsatany participatingeligibleretailpharmacy in theUnitedStates. Productmustoriginate in the United States. •Thisvoucher is thepropertyofMerck andmustbeturnedinonrequest. •Merck reserves theright to rescind, revoke,oramend this offer at anytimewithout notice. • It is illegal to sell, purchase, trade, or counterfeit this voucher. Void if reproduced. Void where prohibited by law, taxed, or restricted. • Please read theaccompanyingMedication Guideand discussitwithyour doctor. Also available is the physician Prescribing Information. • Expiration Date: 7/31/2011
RxBIN No: 610524 RxPCN: 1016 RxGroup: 40025667 • Stay on your prescribed diet and exercise program while taking JANUVIA.
• Talk to your doctor about how to prevent, recognize and manage low blood sugar (hypoglycemia), high blood sugar (hyperglycemia), and problems you have because of your diabetes.
• Your doctor will check your diabetes with regular blood tests, including your blood sugar levels and your hemoglobin A1C.
What are the possible side effects of JANUVIA? Serious side effects have occurred in people taking JANUVIA. • See “What is the most important information I should know about JANUVIA?”
• Low blood sugar (hypoglycemia). If you take JANUVIA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea medicine or insulin may need to be lowered while you use JANUVIA. Signs and symptoms of low blood sugar may include:
• headache • drowsiness • weakness • dizziness • confusion
The most common side effects of JANUVIA include: • upper respiratory infection • stuffy or runny nose and sore throat • headache
JANUVIA may have other side effects, including: • stomach upset and diarrhea • swelling of the hands or legs, when JANUVIA is used with rosiglitazone (Avandia®
of diabetes medicine. ). Rosiglitazone is another type
These are not all the possible side effects of JANUVIA. For more information, ask your doctor or pharmacist. Tell your doctor if you have any side effect that bothers you, is unusual or does not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. How should I store JANUVIA? Store JANUVIA at 68°F to 77°F (20°C to 25°C). Keep JANUVIA and all medicines out of the reach of children. General information about the use of JANUVIA
Medicines are sometimes prescribed for purposes that are not listed in Medication Guides. Do not use JANUVIA for a condition for which it was not prescribed. Do not give JANUVIA to other people, even if they have the same symptoms you have. It may harm them.
This Medication Guide summarizes the most important information about JANUVIA. If you would like to know more information, talk with your doctor. You can ask your doctor or pharmacist for additional information about JANUVIA that is written for health professionals. For more information, go to
www.JANUVIA.com or call 1-800-622-4477.
What are the ingredients in JANUVIA? Active ingredient: sitagliptin.
Inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate. The tablet film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and yellow iron oxide.
What is type 2 diabetes?
Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should. Your body can also make too much sugar. When this happens, sugar (glucose) builds up in the blood. This can lead to serious medical problems.
Avandia®
High blood sugar can be lowered by diet and exercise, and by certain medicines when necessary. JANUVIA®
Copyright©2010 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved Revised February 2010
Manufactured by: Merck Sharp & Dohme (Italia) S.p.A. Via Emilia, 21 27100 – Pavia, Italy 9984400 This Medication Guide has been approved by the U.S. Food and Drug Administration.
is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. is a registered trademark of GlaxoSmithKline.
• irritability • hunger
• fast heart beat • sweating
• feeling jittery
• Serious allergic reactions. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. See “Who should not take JANUVIA?”. Your doctor may give you a medicine for your allergic reaction and prescribe a different medicine for your diabetes.
Issuer: (80840) ID: 719200563
Dose _____mg Offer valid for up to 30 tablets.
• Submit claimtoMcKessonCorporation usingBIN No.610524. Forpharmacyprocessingquestions, please call theHelp Desk at 800-657-7613. •For allother prescriptions, please usethe patient’sprimary method of paymentandanew Rx number. •Byprocessing this voucher, youagree that no claimfor paymentorreimbursement maybesubmitted for this free trialsupplytoany patientorany third-party payer, including federal or state health care programs (Medicaid, Medicare [including true out-of-pocket expense (TrOOP)], or any other state or federal medical or pharmaceutical benefit or pharmaceutical assistance program), private insurers, and health or pharmacy benefit plans.
•For auditing purposes,acopyofthisvoucher must be attached to theoriginalprescriptionand retained by thepharmacy.McKessonCorporation reservesthe righttoreviewall records and documentation relating to the dispensing of product.
20950120(30)(400)-JAN
THIS VOUCHER IS NOT INSURANCE.
See free offer below.*
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