The Freshman Research Initiative:
Continued from Page 25
Research Streams
Nucleic Acid Aptamer
Selection
Professor Andrew Ellington
Dr. Brad Hall
How can we use biochemistry
and nucleic acids for drug devel-
opment and sensor applications?
In this FRI Stream, undergraduates
perform in vitro nucleic acid selec-
tion experiments against a variety of
biomedically relevant protein and cell
targets. They learn about both the
underlying biochemistry of nucleic
acid structure and function, along
with human disease and the process
of biopolymer drug and sensor de-
velopment. In the lab, students plan
research goals, learn molecular biol-
ogy techniques, design and construct
experiments, and analyze and archive
data. As a result, students are in a
position to apply their knowledge and
techniques to new problems of their
own design.
Functional Materials Based
on Metal Complexes
Professor Richard Jones
Professor Brad Holliday
Dr. Xiaoping Yang
How do we make and character-
ize new metal-containing com-
pounds that have useful proper-
ties?
Some chemical compounds that con-
tain metal atoms have useful proper-
ties such as luminescence, or the abil-
ity to “glow in the dark.” The efficien-
cy or brightness of these compounds
is related to the specific arrangement
of the atoms within the chemical
structure. In this FRI Stream, students
learn to make new luminescent com-
pounds and, using state-of-the-art
techniques, explore both the exact
chemical structure (X-ray diffraction)
and luminescence properties (fluo-
rescence and phosphorescence). The
relationship between chemical struc-
ture and physical properties is studied
30
to develop new functional materials.
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