The AVATAR™ Cell Control System True Predictive Medicine.
Faster, Better, More Biologically Relevant Cells
Tissues in the human body are both hypoxic and pressurized. They are made up of diverse micro environments that influence the behavior and molecular profiles of cells.
Standard incubators often perform poorly when tasked with keeping primary cells alive and thriving in culture. These systems control for temperature and CO2, and are tailored for cell lines acclimated to this environment. Cells in the body are exposed to a dramatic gradient of oxygen and fluid pressures ranging from a highly pressurized, hypoxic tumor environment to the high pressure sheer forces of the blood. Whether you’re modeling the immunosuppressive tumor microenvironment, or looking for a condition to drive expansive growth, fine control of oxygen and external pressures are a powerful tool for primary cell optimization.
Why would you culture any cells from the blood at 21% O2 and atmospheric pressure?
The AVATAR™ Cell Control System enables you to mimic the human condition by controlling both oxygen and pressure. It is ideal for immunotherapy applications enabling cell growth and expansion tailored for a specific cell source.
The AVATAR™ Cell Control System works with a variety of cell types including:
• Immune Cell Expansion (T-cells, NK-cells, macrophages) • Stem Cells (iPSCs, NPCs, Cardiomyocytes) • Tumor Cells and Organoids (2D and 3D)
The AVATAR™ Cell Control System Includes:
1. Tumor/tissue dissociation buffers 2. Serum-free culture medium 3. Expert-backed protocols 4. Pressurized-hypoxic systems
Demand for new immune cell therapies, such as CAR-T, has far outpaced the tools to develop and validate them. Modeling primary immune and tumor cell functional interactions under a tumor microenvironment can ensure optimal efficacy and persistence in vivo.
Using the AVATAR Cell Control System, environmental control enables modeling of phenotypic changes that affect target validation and lead characterization for potential cell therapies.
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Live-cell imaging of CAR-T killing assay with primary tumor cells under time-lapse
Environmental control enables modeling of phenotypic changes that affect target validation and lead characterization for potential cell therapies.
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