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Lab Automation


“Those engaged with drug discovery workflows


typically face two key challenges – how can I achieve accurate results, and how can I do this as efficiently as possible,” notes Randy Dyer, Director of Product Marketing at Labcyte Inc. “Non-contact liquid handling techniques, and in particular acous- tic liquid handlers, are allowing scientists to obtain accurate data with fewer steps and much less sam- ple and reagent. The time and cost saved from the increased efficiency has a positive impact on work- flows that occur upstream or downstream of where acoustic liquid handling is used and can lead to the development of entirely new approaches.” The latest generation of liquid handling systems


is also enabling the routine use of much higher density microplates, such as 1536-well formats. Accurate, reliable and consistent liquid handling on this scale has opened up a wealth of applica- tions for ultra-high-throughput experimentation within drug discovery, helping pharmaceutical companies find innovative drugs faster and more resource-efficient.


Commercially-available automated liquid handling systems Modern liquid handling systems are enhancing throughput, improving accuracy and minimising the potential for human error in drug discovery workflows. Here we provide a summary of some of the key products available on the market:


The Agilent Bravo Automated Liquid Handling Platform is a compact system that can fit in a lam- inar flow hood. The Bravo platform utilises a choice of four pipette heads to accurately dispense volumes from 300nL to 250µL in 96-, 384- and 1536-well microplates, with disposable tips for specific applications. The swappable pipette heads, user-configurable deck and ability to pick up tips using a single barrel, row, column or array of bar- rels allow easy customisation to meet specific assay needs. The system’s open design allows access from all sides, facilitating system integration as well as standalone use. With an even smaller bench footprint, the


Agilent Vertical Pipetting Station’s unique eight- microplate position design features a two-axis positioning stage that allows it to integrate seam- lessly into automation systems. The vertical pipet- tor uses high-accuracy heads to dispense volumes from 100nL to 250µL in 96-, 384- and 1536-well microplates with a positioning precision of ±0.025mm. The system delivers industry-leading speed, with an average cycle time of approximately 10 seconds for a microplate transfer and can


Drug Discovery World Winter 2018/19


pipette while other microplates are changed to fur- ther reduce assay time.


Labcyte’s Echo Liquid Handlers use sound energy to achieve a fully non-contact acoustic liquid han- dling workflow from sample storage to assay- ready plates, eliminating compound loss, cross- contamination, carryover or exposure to leachates. The Echo® 655T Liquid Handler is Labcyte’s most advanced system and is designed to support a wide range of applications in drug discovery and funda- mental research. The system provides exceptional precision and is capable of accurately transferring volumes as small as 2.5nL from 384- and 1536- well plates, as well as 96-tube racks. The Echo® 655T system is compatible with the FluidX™ AcoustiX™ Sample Tube technology, developed in partnership with Brooks Life Sciences. The AcoustiX tubes support more efficient sample util- isation and enable ultra-high-density storage. When fully automated workflows are required,


the Echo® 655T system can be integrated with Labcyte’s configurable Access™ Dual Robot System to achieve optimal levels of throughput. The compact and ergonomic platform design fea- tures docking modules, turntables, retractable shelves and drawers, and can be supplemented with environmental management features to pro- tect samples from evaporation or hydration.


PerkinElmer offers a broad range of automated liq- uid handling solutions that can be configured according to the needs of users’ specific applica- tions. The JANUS® G3 series of automated liquid handling workstations is comprised of four differ- ent models (the Mini, Standard, Expanded and Integrator) that vary in terms of deck size and pipetting arm technology. With the options of the Varispan™ arm technology and/or automatic inter- changeable 96 and 384-well Multidisplacement Technology (MDT), users have customised flexibil- ity in throughput, capacity and dynamic volume range. PerkinElmer’s Zephyr® G3 range of liquid han-


dling workstations includes compact systems with a small footprint, making them well-suited for bench operation with a focus on Next Generation Sequencing. The open deck design enables easy access from all four sides, allowing rapid replace- ment of consumables. The Zephyr® G3 series offers a range of useful features, including the ability to hold lids while dispensing, row- and col- umn-wise serial dilutions, partial tips loading, bar- code identification and seamless integration capa- bilities, to simplify liquid handling workflows and


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