Lab Automation
Figure 2
The D300e Digital Dispenser can be used in assay
development and target
validation applications, where high flexibility and easy operation with little programming is needed
maximise efficiency. These attributes provide the flexibility in the Zephyr® G3 NGS solution, com- bining the features with ready to use NGS meth- ods, making the Zephyr® workstation an applica- tion specific solution.
Tecan is driving assay miniaturisation with the D300e Digital Dispenser. Based on proven thermal inkjet technology from HP Inc, it can dispense vol- umes of between 11pL and 10µL directly from the stock solution into the assay plate. The dead vol- ume can be as low as 2µL, which is especially important when compounds are only available in small quantities. The D300e Digital Dispenser’s main application
is not HTS, rather assay development and target validation, where high flexibility and easy opera- tion with little programming is needed. The intu- itive D300e control software allows users to run experiments in minutes, thanks to the ability to transfer existing plate layouts from Microsoft Excel into the software. The built-in software wiz- ards not only facilitate dose-response experiment set-up but also the layout of complex assays, such as drug-drug synergy assays with two or more compounds, with the possibility to normalise and even randomise the plate layouts to reduce edge effects. The platform is capable of using SLAS/ANSI format plates with 12 to 1536 wells, which easily accommodates the transfer of manual
18
96-well assay into higher density plate formats for HTS assay development.
The Thermo Fisher Scientific Versette™ Auto- mated Liquid Handler is a compact and flexible system designed to meet the needs of most labora- tories. With a choice of 96- and 384-channel pipet- ting heads for volume ranges from 0.5 to 300µL, and featuring user-friendly programming, the auto- mated system is well-suited for a broad range of liquid handling applications, including the replica- tion of 96- or 384-well plates, the stamping of microtiter plates and serial dilution. The Thermo Scientific Multidrop™ Combi
Reagent Dispenser offers fast dispensing and high- throughput operation and can handle a wide range of microplate sizes and volume ranges. Delivering precise liquid dispensing over a 0.5 to 2,500µL range and accommodating 6- to 1536-well plates, the automated system is highly flexible and uses eight-channel detachable and autoclavable dispens- ing cassettes that are standard across the Multidrop™ range. The system features an icon- based graphic display that makes it easy to use and programme, and enhanced functionality and flexi- bility can be achieved when used with Thermo Scientific FILLit software.
TTP Labtech’s mosquito® automated liquid han- dlers use individual pistons, rather than air gaps or
Drug Discovery World Winter 2018/19
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