search.noResults

search.searching

dataCollection.invalidEmail
note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Head of Digital Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Design & Production Melissa Chadderton rhubarbcreative@sky.com


USAdvertising Manager Jonathan Sismey Jonathan@rwwcompany.com


EditorialAdvisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard DrTimothyWells Dr Rene Ziegler


Drug DiscoveryWorld (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39Vineyard Path, London SW14 8EL,United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


The US annual subscription price is USD140. Airfreight and mailing in the USA by agent namedWN Shipping USA, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434,USA. Periodicals postage paid at Jamaica NY 11431. US Postmaster: Send address changes to DRUG DISCOVERYWORLD DDW,WN Shipping USA, 156- 15, 146th Avenue, 2nd Floor, Jamaica,NY 11434,USA. Subscription records are maintained at RJ Communications & Media Ltd, 39Vineyard Path, London SW14 8EL,United Kingdom. Air Business Ltd is acting as our mailing agent.


© 2019 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug DiscoveryWorld.


d r u g d i s c o v e r y wo r l d contents VOLUME 20 ISSUE 3 ● SUMMER 2019


Introduction Dr Roger Brimblecombe Consultant Editor


Business The Reality of Virtual Pharmaceutical Companies Dr Stephen Naylor and Dr Kirkwood A. Pritchard Jr


LabAutomation Automating Automation – How Close are we to Artificial Intelligence Impact? Dr Michael A. Tarsellia, Dr Yohann Potier and Dr Alan E. Fletcher


Cell-BasedAssays Automated Cell-Based Assays: Novel Tools Overcome the Barriers to Drug Discovery Success Helen Stewart-Miller and Kate Tointon


Drug Discovery Fail Early, Fail Fast – a Phenotypic Approach Dr Anne-Marie Zuurmond, Dr Geraldine Servant, Dr Lieke Geerts, Dr Laure Grand Moursel, Dr Jeroen DeGroot and Dr Ian Waddell


LabAutomation Safety First – Automating Cell Line Development John Newman-Smith


Therapeutics Cell Therapy – Falling Short of its Potential? Pierre-Louis Joffrin


Precision Medicine From Human Genome to Global Genome – Why Precision Medicine Must Address Genetic Diversity Sumit Jamuar, Dr Jonathan Picker, Dr Saumya Jamuar and Dr Yaron Turpaz


Informatics Application of Bioinformatics in Support of Precision Medicine Mike Furness and John Wise


7 8


16 23


34 40 45


56 51


Front cover illustration courtesy of Oliver Burston/Ikon Images/Science Photo Library Drug DiscoveryWorld Summer 2019 5


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64